Setting description

Taxel_therapies more effective in all the biomarker signatures

Simulations setting

PFS distributions


Treatment effects

By subgroup:

subtype var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
—+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
–+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
–++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
-+– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
-+-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
-++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
-+++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
+— param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
+–+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
+-+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
+-++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
++– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
++-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
+++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
++++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1


By signature:

signature var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
all param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
TP53- & AR- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
TP53+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
DRD+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
TEfus+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1

Errors and power


graduation (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 3 264 0 1
TP53- & AR- 1 375 2 1
TP53+ 1 278 1 0
DRD+ 1 100 0 0
TEfus+ 0 260 1 1
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.006 0.528 0.000 0.002
TP53- & AR- 0.002 0.750 0.004 0.002
TP53+ 0.002 0.556 0.002 0.000
DRD+ 0.002 0.200 0.000 0.000
TEfus+ 0.000 0.520 0.002 0.002
futility (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 100 0 74 79
TP53- & AR- 409 0 390 403
TP53+ 229 0 223 231
DRD+ 111 0 183 175
TEfus+ 198 0 191 209
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.200 0 0.148 0.158
TP53- & AR- 0.818 0 0.780 0.806
TP53+ 0.458 0 0.446 0.462
DRD+ 0.222 0 0.366 0.350
TEfus+ 0.396 0 0.382 0.418
max sample size (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0 0 0 0
TP53- & AR- 5 14 30 17
TP53+ 19 77 24 22
DRD+ 0 0 0 0
TEfus+ 1 1 2 2
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.000 0.000 0.000 0.000
TP53- & AR- 0.010 0.028 0.060 0.034
TP53+ 0.038 0.154 0.048 0.044
DRD+ 0.000 0.000 0.000 0.000
TEfus+ 0.002 0.002 0.004 0.004


Errors & power

The overall error was 0.456.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.012             0.440             0.008             0.006 

The overall power was 0.528.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.000             0.528             0.000             0.000 

Median results at the end of the trial

By signature:
signature var Control Hormone_therapies Taxel_therapies Carboplatin Niraparib
all graduation 0 3 264 0 1
futility 0 100 0 74 79
max_n 0 0 0 0 0
n 432 (352, 477) 139 (80, 225) 142 (49, 278) 155 (94, 249) 154 (89, 244)
n_unique 401 (329, 445) 130 (74, 211) 132 (45, 259) 144 (87, 239) 144 (82, 231)
time_trial 36 (36, 36) 36 (25, 36) 32 (8, 36) 36 (33, 36) 36 (31, 36)
time_stop NA (NA, NA) 25 (4, 35) 14 (6, 28) 30 (20, 36) 29 (20, 35)
post_p NA (NA, NA) 0 (0, 0.01) 1 (1, 1) 0 (0, 0.01) 0 (0, 0.01)
rate 0.075 (0.069, 0.081) 0.114 (0.101, 0.131) 0.036 (0.031, 0.041) 0.113 (0.101, 0.129) 0.113 (0.102, 0.13)
TP53- & AR- graduation 0 1 375 2 1
futility 0 409 0 390 403
max_n 0 5 14 30 17
n 166 (99, 203) 39 (25, 105) 31 (18, 116) 47 (26, 136) 42 (25, 123)
n_unique 155 (92, 191) 37 (23, 101) 29 (15, 111) 43 (24, 130) 40 (24, 118)
time_trial 36 (36, 36) 19 (9, 36) 15 (9, 36) 23 (15, 36) 22 (13, 36)
time_stop NA (NA, NA) 17 (9, 30) 12 (9, 24) 21 (14, 31) 20 (13, 31)
post_p NA (NA, NA) 0.02 (0, 0.13) 1 (0.98, 1) 0.02 (0, 0.13) 0.02 (0, 0.14)
rate 0.075 (0.066, 0.085) 0.117 (0.098, 0.151) 0.036 (0.027, 0.046) 0.114 (0.098, 0.145) 0.115 (0.098, 0.142)
TP53+ graduation 0 1 278 1 0
futility 0 229 0 223 231
max_n 0 19 77 24 22
n 200 (173, 226) 66 (27, 120) 59 (25, 152) 71 (35, 127) 70 (32, 132)
n_unique 188 (162, 210) 61 (26, 114) 56 (22, 143) 66 (32, 118) 65 (30, 123)
time_trial 36 (36, 36) 36 (17, 36) 30 (9, 36) 36 (18, 36) 36 (17, 36)
time_stop NA (NA, NA) 24 (13, 34) 14 (8, 29) 24 (13, 34) 24 (15, 33)
post_p NA (NA, NA) 0.01 (0, 0.11) 1 (0.99, 1) 0.01 (0, 0.09) 0.01 (0, 0.09)
rate 0.075 (0.067, 0.084) 0.114 (0.096, 0.142) 0.036 (0.029, 0.044) 0.114 (0.098, 0.137) 0.114 (0.099, 0.142)
DRD+ graduation 0 1 100 0 0
futility 0 111 0 183 175
max_n 0 0 0 0 0
n 112 (90, 133) 41 (19, 69) 26 (5, 59) 55 (33, 80) 53 (29, 83)
n_unique 105 (83, 123) 38 (17, 63) 24 (5, 56) 51 (30, 76) 49 (27, 78)
time_trial 36 (36, 36) 36 (29, 36) 36 (24, 36) 36 (22, 36) 36 (20, 36)
time_stop NA (NA, NA) 30 (23, 35) 24 (16, 33) 26 (17, 34) 24 (16, 34)
post_p NA (NA, NA) 0.04 (0, 0.26) 1 (0.87, 1) 0.02 (0, 0.15) 0.02 (0, 0.16)
rate 0.075 (0.064, 0.086) 0.114 (0.093, 0.156) 0.036 (0.023, 0.051) 0.116 (0.096, 0.141) 0.114 (0.096, 0.145)
TEfus+ graduation 0 0 260 1 1
futility 0 198 0 191 209
max_n 0 1 1 2 2
n 155 (127, 178) 54 (25, 91) 43 (20, 103) 62 (33, 101) 59 (30, 105)
n_unique 144 (118, 167) 50 (23, 85) 39 (18, 97) 57 (31, 95) 54 (27, 96)
time_trial 36 (36, 36) 36 (21, 36) 33 (11, 36) 36 (20, 36) 36 (18, 36)
time_stop NA (NA, NA) 26 (17, 34) 15 (10, 29) 25 (17, 34) 23 (15, 35)
post_p NA (NA, NA) 0.02 (0, 0.16) 1 (0.99, 1) 0.02 (0, 0.15) 0.01 (0, 0.13)
rate 0.075 (0.066, 0.085) 0.115 (0.096, 0.144) 0.037 (0.028, 0.045) 0.113 (0.096, 0.138) 0.115 (0.097, 0.145)


By subgroup combinations:
subtype var Control Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- graduation 0 442 464 396 412
futility 0 0 0 0 0
max_n 0 5 14 30 17
n 108 (63, 135) 23 (15, 67) 22 (10, 83) 24 (9, 86) 21 (8, 83)
n_unique 101 (57, 127) 22 (14, 66) 21 (10, 80) 22 (8, 83) 20 (7, 79)
post_p NA (NA, NA) 0.06 (0, 0.26) 1 (0.92, 1) 0.08 (0, 0.3) 0.07 (0, 0.33)
rate 0.075 (0.064, 0.087) 0.117 (0.093, 0.157) 0.035 (0.026, 0.049) 0.115 (0.093, 0.173) 0.115 (0.091, 0.173)
—+ graduation 0 457 469 410 429
futility 0 0 0 0 0
max_n 0 5 14 31 19
n 18 (10, 27) 6 (2, 15) 5 (2, 12) 6 (2, 16) 5 (2, 17)
n_unique 17 (9, 25) 5 (2, 14) 5 (2, 11) 5 (2, 16) 5 (1, 16)
post_p NA (NA, NA) 0.26 (0.09, 0.54) 0.87 (0.53, 0.99) 0.28 (0.11, 0.62) 0.28 (0.1, 0.58)
rate 0.074 (0.05, 0.111) 0.134 (0.082, 0.304) 0.037 (0.017, 0.079) 0.126 (0.073, 0.283) 0.13 (0.076, 0.392)
–+- graduation 0 260 360 227 234
futility 0 0 0 0 0
max_n 0 19 73 24 22
n 69 (57, 83) 16 (7, 51) 22 (6, 63) 16 (5, 51) 15 (5, 52)
n_unique 66 (54, 78) 15 (6, 49) 21 (5, 61) 15 (5, 49) 14 (5, 49)
post_p NA (NA, NA) 0.12 (0.02, 0.36) 1 (0.83, 1) 0.12 (0.03, 0.44) 0.13 (0.02, 0.41)
rate 0.076 (0.062, 0.092) 0.12 (0.091, 0.196) 0.036 (0.023, 0.054) 0.121 (0.088, 0.211) 0.12 (0.089, 0.23)
–++ graduation 0 331 415 292 297
futility 0 0 0 0 0
max_n 0 19 71 25 23
n 46 (33, 56) 12 (4, 33) 14 (6, 40) 11 (4, 33) 10 (4, 34)
n_unique 43 (31, 54) 11 (3, 31) 13 (5, 37) 10 (3, 32) 9 (3, 32)
post_p NA (NA, NA) 0.19 (0.05, 0.47) 0.98 (0.76, 1) 0.2 (0.04, 0.51) 0.18 (0.04, 0.46)
rate 0.076 (0.06, 0.096) 0.119 (0.084, 0.239) 0.038 (0.023, 0.058) 0.121 (0.082, 0.22) 0.125 (0.086, 0.241)
-+– graduation 0 449 467 414 425
futility 0 0 0 0 0
max_n 0 5 14 30 17
n 19 (10, 27) 4 (0, 14) 3 (0, 11) 8 (3, 20) 8 (3, 19)
n_unique 17 (8, 26) 4 (0, 14) 2 (0, 10) 7 (3, 19) 7 (2, 18)
post_p NA (NA, NA) 0.3 (0.12, 0.57) 0.8 (0.48, 0.97) 0.27 (0.09, 0.54) 0.26 (0.09, 0.54)
rate 0.074 (0.051, 0.107) 0.137 (0.077, 0.494) 0.039 (0.008, 0.091) 0.124 (0.079, 0.265) 0.121 (0.08, 0.244)
-+-+ graduation 0 465 472 423 438
futility 0 0 0 0 0
max_n 0 4 14 31 19
n 17 (9, 27) 4 (0, 13) 3 (0, 9) 8 (3, 20) 6 (2, 19)
n_unique 16 (8, 25) 4 (0, 13) 2 (0, 8) 8 (3, 19) 6 (2, 17)
post_p NA (NA, NA) 0.31 (0.14, 0.59) 0.82 (0.48, 0.98) 0.29 (0.1, 0.61) 0.27 (0.09, 0.59)
rate 0.078 (0.051, 0.113) 0.136 (0.079, 0.411) 0.039 (0, 0.101) 0.12 (0.078, 0.29) 0.128 (0.082, 0.347)
-++- graduation 0 286 381 281 280
futility 0 0 0 0 0
max_n 0 19 71 22 22
n 13 (8, 18) 4 (1, 11) 2 (0, 9) 5 (2, 12) 5 (2, 12)
n_unique 12 (7, 17) 4 (1, 10) 2 (0, 9) 5 (2, 12) 5 (1, 11)
post_p NA (NA, NA) 0.34 (0.16, 0.61) 0.77 (0.4, 0.95) 0.31 (0.14, 0.62) 0.32 (0.15, 0.6)
rate 0.075 (0.048, 0.118) 0.127 (0.072, 0.395) 0.041 (0, 0.14) 0.127 (0.073, 0.316) 0.125 (0.07, 0.336)
-+++ graduation 0 342 423 327 326
futility 0 0 0 0 0
max_n 0 19 69 23 23
n 12 (7, 17) 4 (0, 10) 2 (0, 7) 5 (2, 13) 5 (1, 13)
n_unique 11 (6, 16) 3 (0, 10) 2 (0, 7) 5 (1, 12) 5 (1, 12)
post_p NA (NA, NA) 0.35 (0.16, 0.65) 0.77 (0.41, 0.95) 0.32 (0.14, 0.59) 0.32 (0.15, 0.66)
rate 0.078 (0.046, 0.125) 0.132 (0.072, 0.494) 0.041 (0, 0.119) 0.134 (0.079, 0.39) 0.134 (0.073, 0.348)
+— graduation 0 103 264 74 80
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 22 (15, 28) 5 (2, 16) 13 (3, 26) 6 (2, 15) 6 (2, 15)
n_unique 20 (14, 27) 5 (2, 14) 12 (3, 24) 5 (2, 15) 5 (2, 14)
post_p NA (NA, NA) 0.26 (0.11, 0.57) 0.94 (0.64, 1) 0.28 (0.1, 0.58) 0.28 (0.11, 0.54)
rate 0.076 (0.053, 0.106) 0.129 (0.075, 0.363) 0.035 (0.02, 0.065) 0.128 (0.073, 0.373) 0.128 (0.073, 0.313)
+–+ graduation 0 239 366 196 215
futility 0 0 0 0 0
max_n 0 1 1 2 2
n 18 (12, 24) 5 (2, 14) 7 (2, 18) 5 (2, 14) 5 (2, 14)
n_unique 16 (11, 23) 5 (1, 13) 6 (2, 17) 5 (2, 13) 5 (2, 13)
post_p NA (NA, NA) 0.29 (0.11, 0.59) 0.88 (0.55, 0.98) 0.3 (0.12, 0.58) 0.3 (0.12, 0.56)
rate 0.075 (0.048, 0.117) 0.133 (0.07, 0.388) 0.038 (0.018, 0.075) 0.126 (0.071, 0.333) 0.129 (0.068, 0.389)
+-+- graduation 0 260 360 227 234
futility 0 0 0 0 0
max_n 0 19 73 24 22
n 18 (11, 24) 5 (1, 14) 6 (2, 18) 5 (2, 14) 6 (2, 15)
n_unique 16 (11, 23) 5 (1, 13) 6 (2, 17) 5 (1, 13) 5 (2, 14)
post_p NA (NA, NA) 0.29 (0.13, 0.59) 0.88 (0.52, 0.99) 0.31 (0.12, 0.56) 0.29 (0.12, 0.6)
rate 0.074 (0.051, 0.114) 0.132 (0.068, 0.385) 0.038 (0.017, 0.088) 0.126 (0.074, 0.424) 0.127 (0.068, 0.348)
+-++ graduation 0 331 415 292 297
futility 0 0 0 0 0
max_n 0 19 71 25 23
n 17 (12, 23) 5 (2, 14) 5 (2, 15) 6 (2, 15) 5 (2, 13)
n_unique 16 (10, 22) 4 (1, 12) 5 (1, 15) 5 (1, 14) 5 (2, 13)
post_p NA (NA, NA) 0.3 (0.12, 0.57) 0.88 (0.55, 0.98) 0.31 (0.13, 0.62) 0.3 (0.12, 0.59)
rate 0.075 (0.048, 0.111) 0.125 (0.073, 0.39) 0.036 (0.016, 0.074) 0.122 (0.073, 0.355) 0.129 (0.073, 0.344)
++– graduation 0 167 303 187 182
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 13 (8, 18) 4 (1, 11) 4 (0, 12) 5 (2, 12) 5 (2, 11)
n_unique 12 (7, 17) 4 (1, 10) 4 (0, 11) 4 (2, 11) 4 (2, 10)
post_p NA (NA, NA) 0.35 (0.16, 0.64) 0.8 (0.45, 0.97) 0.32 (0.14, 0.6) 0.32 (0.14, 0.59)
rate 0.075 (0.044, 0.12) 0.126 (0.064, 0.421) 0.038 (0.003, 0.107) 0.13 (0.076, 0.382) 0.128 (0.071, 0.415)
++-+ graduation 0 276 389 260 272
futility 0 0 0 0 0
max_n 0 0 1 2 2
n 12 (7, 19) 4 (1, 11) 2 (0, 10) 5 (2, 11) 5 (2, 13)
n_unique 12 (7, 17) 4 (1, 10) 2 (0, 9) 5 (1, 11) 5 (1, 12)
post_p NA (NA, NA) 0.34 (0.16, 0.65) 0.81 (0.43, 0.97) 0.32 (0.14, 0.61) 0.33 (0.13, 0.63)
rate 0.077 (0.046, 0.13) 0.132 (0.068, 0.359) 0.039 (0, 0.127) 0.128 (0.076, 0.411) 0.129 (0.072, 0.377)
+++- graduation 0 286 381 281 280
futility 0 0 0 0 0
max_n 0 19 71 22 22
n 13 (8, 18) 4 (1, 11) 2 (0, 9) 5 (1, 12) 5 (2, 12)
n_unique 11 (7, 17) 4 (1, 10) 2 (0, 9) 5 (1, 12) 5 (2, 11)
post_p NA (NA, NA) 0.34 (0.15, 0.63) 0.8 (0.45, 0.96) 0.31 (0.13, 0.59) 0.33 (0.15, 0.6)
rate 0.076 (0.048, 0.126) 0.13 (0.068, 0.421) 0.035 (0, 0.114) 0.133 (0.076, 0.396) 0.127 (0.075, 0.302)
++++ graduation 0 342 423 327 326
futility 0 0 0 0 0
max_n 0 19 69 23 23
n 12 (7, 17) 4 (1, 11) 2 (0, 7) 5 (2, 13) 5 (2, 12)
n_unique 11 (7, 16) 4 (0, 10) 2 (0, 7) 5 (1, 12) 5 (1, 11)
post_p NA (NA, NA) 0.35 (0.16, 0.66) 0.78 (0.42, 0.96) 0.32 (0.14, 0.62) 0.31 (0.14, 0.62)
rate 0.076 (0.046, 0.125) 0.135 (0.068, 0.371) 0.04 (0, 0.138) 0.13 (0.072, 0.407) 0.136 (0.073, 0.362)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 3 264 1
time_stop 3 (3, 5) 14 (6, 28) 7 (7, 7)
n_trt 27 (27, 34) 86 (37, 202) 31 (31, 31)
n_control 34 (34, 56) 146 (65, 327) 75 (75, 75)
post_p 0.94 (0.9, 0.95) 1 (0.98, 1) 0.88 (0.88, 0.88)
order 1 (1, 1) 2 (1, 3) 1 (1, 1)
TP53- & AR- count 1 375 2 1
time_stop 13 (13, 13) 12 (9, 24) 12 (12, 13) 15 (15, 15)
n_trt 32 (32, 32) 33 (25, 83) 30 (26, 33) 26 (26, 26)
n_control 64 (64, 64) 53 (35, 118) 60 (58, 62) 74 (74, 74)
post_p 0.88 (0.88, 0.88) 0.98 (0.91, 1) 0.93 (0.92, 0.94) 0.97 (0.97, 0.97)
order 3 (3, 3) 1 (1, 3) 4 (4, 4) 4 (4, 4)
TP53+ count 1 278 1
time_stop 7 (7, 7) 14 (8, 29) 10 (10, 10)
n_trt 26 (26, 26) 44 (27, 113) 27 (27, 27)
n_control 26 (26, 26) 64 (36, 156) 51 (51, 51)
post_p 0.93 (0.93, 0.93) 1 (0.95, 1) 0.92 (0.92, 0.92)
order 1 (1, 1) 2 (1, 4) 1 (1, 1)
DRD+ count 1 100
time_stop 15 (15, 15) 24 (16, 33)
n_trt 26 (26, 26) 30 (25, 55)
n_control 41 (41, 41) 66 (41, 101)
post_p 0.86 (0.86, 0.86) 1 (0.98, 1)
order 5 (5, 5) 3 (1, 5)
TEfus+ count 260 1 1
time_stop 15 (10, 29) 10 (10, 10) 12 (12, 12)
n_trt 38 (26, 77) 26 (26, 26) 25 (25, 25)
n_control 60 (35, 126) 42 (42, 42) 49 (49, 49)
post_p 1 (0.97, 1) 0.91 (0.91, 0.91) 0.95 (0.95, 0.95)
order 2 (1, 4) 2 (2, 2) 2 (2, 2)
Futility:
signature var Hormone_therapies Carboplatin Niraparib
all count 100 74 79
time_stop 26 (4, 35) 30 (20, 36) 29 (21, 35)
n_trt 88 (28, 167) 116 (80, 197) 106 (72, 173)
n_control 281 (38, 419) 333 (225, 429) 321 (223, 410)
post_p 0 (0, 0.11) 0 (0, 0.01) 0 (0, 0)
order 5.5 (1, 9) 6 (3.3, 9) 6 (3, 9)
TP53- & AR- count 409 390 403
time_stop 17 (9, 30) 21 (14, 31) 20 (13, 31)
n_trt 37 (25, 87) 40 (25, 93) 37 (25, 93)
n_control 75 (36, 149) 102 (60, 162) 96 (55, 162)
post_p 0.07 (0, 0.23) 0.06 (0, 0.19) 0.06 (0, 0.2)
order 2 (1, 5) 3 (1, 6) 3 (1, 6)
TP53+ count 229 223 231
time_stop 24 (13, 34) 24 (14, 34) 24 (15, 33)
n_trt 49 (28, 109) 49 (28, 95) 49 (27, 89)
n_control 129 (58, 194) 130 (63, 190) 123 (66, 185)
post_p 0.01 (0, 0.09) 0.01 (0, 0.08) 0.01 (0, 0.07)
order 4 (1, 8) 4 (1, 7) 4 (1, 8)
DRD+ count 111 183 175
time_stop 30 (23, 35) 26 (17, 34) 24 (16, 34)
n_trt 37 (26, 58) 43 (29, 67) 39 (27, 57)
n_control 93 (67, 123) 82 (49, 111) 73 (43, 110)
post_p 0.01 (0, 0.06) 0.01 (0, 0.07) 0.01 (0, 0.08)
order 6 (3, 9) 5 (2, 8) 4 (2, 9)
TEfus+ count 198 191 209
time_stop 26 (17, 34) 25 (17, 34) 23 (15, 35)
n_trt 44 (26, 74) 47 (29, 75) 41 (26, 70)
n_control 108 (64, 153) 107 (69, 149) 98 (59, 152)
post_p 0.02 (0, 0.08) 0.01 (0, 0.07) 0.01 (0, 0.06)
order 5 (2, 9) 5 (2, 9) 5 (2, 8)


By subgroup combinations

Graduation:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Hormone_therapies count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
time 3 (3, 5) 3 (3, 5) 3 (3, 5) 3 (3, 5) 3 (3, 5) 3 (3, 5) 3 (3, 5) 3 (3, 5) 3 (3, 5) 3 (3, 5) 3 (3, 5) 3 (3, 5) 3 (3, 5) 3 (3, 5) 3 (3, 5) 3 (3, 5)
n 14 (12, 16) 2 (2, 2) 8 (7, 9) 2 (1, 3) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 2) 0 (0, 1) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 2) 0 (0, 0)
post_p 0.63 (0.58, 0.73) 0.54 (0.52, 0.56) 0.63 (0.55, 0.7) 0.6 (0.58, 0.61) 0.58 (0.58, 0.58) 0.53 (0.53, 0.53) NA (NA, NA) NA (NA, NA) 0.61 (0.61, 0.61) 0.64 (0.64, 0.64) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.53 (0.53, 0.53) NA (NA, NA)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.076 (0.05, 0.083) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA)
Taxel_therapies count 264 264 264 264 264 264 264 264 264 264 264 264 264 264 264 264
time 14 (6, 28) 14 (6, 28) 14 (6, 28) 14 (6, 28) 14 (6, 28) 14 (6, 28) 14 (6, 28) 14 (6, 28) 14 (6, 28) 14 (6, 28) 14 (6, 28) 14 (6, 28) 14 (6, 28) 14 (6, 28) 14 (6, 28) 14 (6, 28)
n 19 (7, 46) 4 (2, 10) 13 (4, 41) 12 (5, 27) 2 (0, 7) 2 (0, 6) 2 (0, 6) 1 (0, 5) 7 (2, 16) 5 (2, 12) 4 (1, 10) 4 (1, 10) 2 (0, 6) 1 (0, 6) 1 (0, 6) 1 (0, 5)
post_p 0.92 (0.62, 1) 0.74 (0.55, 0.95) 0.85 (0.58, 1) 0.8 (0.57, 0.98) 0.66 (0.52, 0.89) 0.68 (0.53, 0.88) 0.66 (0.54, 0.86) 0.63 (0.52, 0.85) 0.75 (0.54, 0.97) 0.68 (0.53, 0.93) 0.67 (0.53, 0.89) 0.69 (0.53, 0.92) 0.64 (0.52, 0.87) 0.64 (0.52, 0.89) 0.63 (0.51, 0.9) 0.66 (0.52, 0.88)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.033 (0, 0.058) 0.022 (0, 0.072) 0.032 (0, 0.063) 0.035 (0, 0.065) 0 (0, 0.068) 0 (0, 0.075) 0 (0, 0.064) 0 (0, 0.084) 0.028 (0, 0.062) 0.022 (0, 0.069) 0.029 (0, 0.074) 0.023 (0, 0.08) 0 (0, 0.076) 0 (0, 0.071) 0 (0, 0.074) 0 (0, 0.061)
Niraparib count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
time 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7)
n 7 (7, 7) 1 (1, 1) 5 (5, 5) 1 (1, 1) 2 (2, 2) 2 (2, 2) 2 (2, 2) 0 (0, 0) 0 (0, 0) 1 (1, 1) 5 (5, 5) 0 (0, 0) 3 (3, 3) 1 (1, 1) 0 (0, 0) 1 (1, 1)
post_p 0.5 (0.5, 0.5) 0.51 (0.51, 0.51) 0.55 (0.55, 0.55) 0.54 (0.54, 0.54) 0.64 (0.64, 0.64) 0.69 (0.69, 0.69) 0.61 (0.61, 0.61) NA (NA, NA) NA (NA, NA) 0.56 (0.56, 0.56) 0.57 (0.57, 0.57) NA (NA, NA) 0.62 (0.62, 0.62) 0.57 (0.57, 0.57) NA (NA, NA) 0.58 (0.58, 0.58)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.074 (0.074, 0.074) 0 (0, 0) 0.059 (0.059, 0.059) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0.081 (0.081, 0.081) 0 (0, 0) NA (NA, NA) 0 (0, 0)
TP53- & AR- Hormone_therapies count 1 1 1 1
time 13 (13, 13) 13 (13, 13) 13 (13, 13) 13 (13, 13)
n 23 (23, 23) 5 (5, 5) 4 (4, 4) 0 (0, 0)
post_p 0.83 (0.83, 0.83) 0.54 (0.54, 0.54) 0.56 (0.56, 0.56) NA (NA, NA)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.074 (0.074, 0.074) 0.059 (0.059, 0.059) 0.071 (0.071, 0.071) NA (NA, NA)
Taxel_therapies count 375 375 375 375
time 12 (9, 24) 12 (9, 24) 12 (9, 24) 12 (9, 24)
n 23 (16, 59) 5 (2, 11) 3 (1, 9) 3 (0, 8)
post_p 0.92 (0.76, 1) 0.74 (0.55, 0.91) 0.64 (0.52, 0.86) 0.64 (0.52, 0.89)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.032 (0.014, 0.051) 0.026 (0, 0.071) 0 (0, 0.074) 0 (0, 0.08)
Carboplatin count 2 2 2 2
time 12 (12, 13) 12 (12, 13) 12 (12, 13) 12 (12, 13)
n 14 (9, 19) 2 (2, 3) 4 (3, 5) 9 (7, 11)
post_p 0.79 (0.76, 0.81) 0.56 (0.54, 0.59) 0.57 (0.52, 0.61) 0.79 (0.74, 0.85)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.022 (0.004, 0.04) 0 (0, 0) 0.082 (0.056, 0.109) 0.039 (0.037, 0.041)
Niraparib count 1 1 1 1
time 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15)
n 16 (16, 16) 1 (1, 1) 5 (5, 5) 4 (4, 4)
post_p 0.78 (0.78, 0.78) 0.54 (0.54, 0.54) 0.84 (0.84, 0.84) 0.53 (0.53, 0.53)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.053 (0.053, 0.053) 0 (0, 0) 0 (0, 0) 0.072 (0.072, 0.072)
TP53+ Hormone_therapies count 1 1 1 1 1 1 1 1
time 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7)
n 16 (16, 16) 4 (4, 4) 1 (1, 1) 0 (0, 0) 2 (2, 2) 3 (3, 3) 0 (0, 0) 0 (0, 0)
post_p 0.84 (0.84, 0.84) 0.6 (0.6, 0.6) 0.58 (0.58, 0.58) NA (NA, NA) 0.63 (0.63, 0.63) 0.53 (0.53, 0.53) NA (NA, NA) NA (NA, NA)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.031 (0.031, 0.031) 0.064 (0.064, 0.064) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA)
Taxel_therapies count 278 278 278 278 278 278 278 278
time 14 (8, 29) 14 (8, 29) 14 (8, 29) 14 (8, 29) 14 (8, 29) 14 (8, 29) 14 (8, 29) 14 (8, 29)
n 16 (7, 47) 13 (7, 27) 2 (0, 6) 1 (0, 5) 5 (2, 12) 4 (2, 12) 2 (0, 6) 2 (0, 6)
post_p 0.89 (0.72, 1) 0.85 (0.71, 0.99) 0.64 (0.52, 0.87) 0.63 (0.52, 0.86) 0.73 (0.53, 0.92) 0.75 (0.54, 0.94) 0.63 (0.52, 0.92) 0.68 (0.52, 0.89)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.033 (0, 0.058) 0.036 (0.011, 0.062) 0 (0, 0.073) 0 (0, 0.071) 0.032 (0, 0.079) 0.024 (0, 0.072) 0 (0, 0.063) 0 (0, 0.072)
Carboplatin count 1 1 1 1 1 1 1 1
time 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10)
n 7 (7, 7) 4 (4, 4) 0 (0, 0) 3 (3, 3) 4 (4, 4) 2 (2, 2) 3 (3, 3) 4 (4, 4)
post_p 0.77 (0.77, 0.77) 0.76 (0.76, 0.76) NA (NA, NA) 0.56 (0.56, 0.56) 0.57 (0.57, 0.57) 0.57 (0.57, 0.57) 0.61 (0.61, 0.61) 0.7 (0.7, 0.7)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.062 (0.062, 0.062) 0 (0, 0) NA (NA, NA) 0.095 (0.095, 0.095) 0.047 (0.047, 0.047) 0 (0, 0) 0 (0, 0) 0.101 (0.101, 0.101)
DRD+ Hormone_therapies count 1 1 1 1 1 1 1 1
time 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15)
n 9 (9, 9) 0 (0, 0) 1 (1, 1) 3 (3, 3) 2 (2, 2) 3 (3, 3) 2 (2, 2) 6 (6, 6)
post_p 0.71 (0.71, 0.71) NA (NA, NA) 0.52 (0.52, 0.52) 0.52 (0.52, 0.52) 0.52 (0.52, 0.52) 0.71 (0.71, 0.71) 0.56 (0.56, 0.56) 0.72 (0.72, 0.72)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.055 (0.055, 0.055) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0.092 (0.092, 0.092) 0.065 (0.065, 0.065) 0.083 (0.083, 0.083) 0.084 (0.084, 0.084)
Taxel_therapies count 100 100 100 100 100 100 100 100
time 24 (16, 33) 24 (16, 33) 24 (16, 33) 24 (16, 33) 24 (16, 33) 24 (16, 33) 24 (16, 33) 24 (16, 33)
n 4 (1, 11) 4 (1, 11) 4 (1, 9) 2 (0, 7) 4 (1, 10) 3 (1, 8) 3 (0, 9) 3 (0, 7)
post_p 0.77 (0.6, 0.94) 0.77 (0.58, 0.94) 0.74 (0.53, 0.93) 0.73 (0.53, 0.89) 0.73 (0.52, 0.93) 0.75 (0.55, 0.95) 0.75 (0.53, 0.92) 0.72 (0.54, 0.9)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.034 (0, 0.069) 0.034 (0, 0.075) 0.026 (0, 0.09) 0.032 (0, 0.089) 0.02 (0, 0.076) 0.019 (0, 0.061) 0.016 (0, 0.083) 0.03 (0, 0.078)
TEfus+ count 260 260 260 260 260 260 260 260
time 15 (10, 29) 15 (10, 29) 15 (10, 29) 15 (10, 29) 15 (10, 29) 15 (10, 29) 15 (10, 29) 15 (10, 29)
n 5 (2, 11) 14 (8, 28) 2 (0, 6) 2 (0, 5) 5 (2, 12) 5 (2, 11) 2 (0, 7) 2 (0, 5)
post_p 0.77 (0.57, 0.95) 0.86 (0.73, 1) 0.7 (0.53, 0.89) 0.66 (0.52, 0.88) 0.74 (0.54, 0.93) 0.77 (0.55, 0.93) 0.67 (0.52, 0.92) 0.66 (0.53, 0.87)
r_prob 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.027 (0, 0.064) 0.035 (0.014, 0.063) 0 (0, 0.079) 0 (0, 0.08) 0.031 (0, 0.069) 0.028 (0, 0.071) 0 (0, 0.069) 0 (0, 0.076)
Carboplatin count 1 1 1 1 1 1 1 1
time 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10)
n 3 (3, 3) 3 (3, 3) 5 (5, 5) 1 (1, 1) 3 (3, 3) 3 (3, 3) 4 (4, 4) 4 (4, 4)
post_p 0.66 (0.66, 0.66) 0.62 (0.62, 0.62) 0.69 (0.69, 0.69) 0.68 (0.68, 0.68) 0.61 (0.61, 0.61) 0.52 (0.52, 0.52) 0.72 (0.72, 0.72) 0.7 (0.7, 0.7)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0) 0 (0, 0) 0.116 (0.116, 0.116) 0 (0, 0) 0 (0, 0) 0.086 (0.086, 0.086) 0.075 (0.075, 0.075) 0 (0, 0)
Niraparib count 1 1 1 1 1 1 1 1
time 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12)
n 2 (2, 2) 4 (4, 4) 5 (5, 5) 2 (2, 2) 0 (0, 0) 4 (4, 4) 4 (4, 4) 4 (4, 4)
post_p 0.54 (0.54, 0.54) 0.67 (0.67, 0.67) 0.66 (0.66, 0.66) 0.54 (0.54, 0.54) NA (NA, NA) 0.63 (0.63, 0.63) 0.71 (0.71, 0.71) 0.58 (0.58, 0.58)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0) 0 (0, 0) 0.042 (0.042, 0.042) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0.046 (0.046, 0.046) 0.038 (0.038, 0.038)
Futility:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Hormone_therapies count 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100
time 26 (4, 35) 26 (4, 35) 26 (4, 35) 26 (4, 35) 26 (4, 35) 26 (4, 35) 26 (4, 35) 26 (4, 35) 26 (4, 35) 26 (4, 35) 26 (4, 35) 26 (4, 35) 26 (4, 35) 26 (4, 35) 26 (4, 35) 26 (4, 35)
n 20 (13, 44) 4 (1, 8) 10 (5, 32) 6 (2, 26) 2 (0, 7) 2 (0, 9) 2 (0, 8) 2 (0, 7) 4 (0, 12) 3 (1, 10) 3 (0, 10) 3 (0, 9) 2 (0, 7) 2 (0, 7) 2 (0, 7) 2 (0, 7)
post_p 0.13 (0.01, 0.41) 0.3 (0.13, 0.45) 0.19 (0.04, 0.43) 0.28 (0.05, 0.46) 0.31 (0.11, 0.42) 0.35 (0.12, 0.46) 0.33 (0.16, 0.47) 0.34 (0.19, 0.48) 0.3 (0.12, 0.45) 0.3 (0.18, 0.48) 0.3 (0.13, 0.47) 0.28 (0.16, 0.46) 0.34 (0.18, 0.45) 0.32 (0.16, 0.49) 0.33 (0.19, 0.44) 0.35 (0.21, 0.47)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.115 (0.088, 0.16) 0.161 (0.079, 0.455) 0.129 (0.082, 0.248) 0.127 (0.081, 0.396) 0.154 (0.083, 0.556) 0.16 (0.07, 0.384) 0.132 (0.072, 0.436) 0.165 (0.08, 0.537) 0.133 (0.068, 0.411) 0.156 (0.063, 0.607) 0.152 (0.086, 0.548) 0.155 (0.087, 0.451) 0.153 (0.076, 0.606) 0.149 (0.085, 0.693) 0.158 (0.081, 0.522) 0.146 (0.092, 0.516)
Carboplatin count 74 74 74 74 74 74 74 74 74 74 74 74 74 74 74 74
time 30 (20, 36) 30 (20, 36) 30 (20, 36) 30 (20, 36) 30 (20, 36) 30 (20, 36) 30 (20, 36) 30 (20, 36) 30 (20, 36) 30 (20, 36) 30 (20, 36) 30 (20, 36) 30 (20, 36) 30 (20, 36) 30 (20, 36) 30 (20, 36)
n 21 (9, 63) 5 (2, 15) 12 (5, 39) 8 (3, 19) 7 (3, 17) 7 (2, 17) 4 (1, 9) 4 (1, 8) 4 (2, 12) 4 (1, 11) 3 (1, 9) 4 (1, 11) 4 (2, 9) 4 (1, 10) 4 (1, 8) 4 (2, 8)
post_p 0.1 (0.01, 0.36) 0.29 (0.12, 0.47) 0.19 (0.05, 0.43) 0.19 (0.06, 0.42) 0.27 (0.12, 0.47) 0.29 (0.1, 0.47) 0.33 (0.18, 0.48) 0.31 (0.15, 0.46) 0.28 (0.11, 0.44) 0.29 (0.16, 0.43) 0.29 (0.16, 0.45) 0.32 (0.15, 0.45) 0.32 (0.17, 0.46) 0.32 (0.12, 0.47) 0.29 (0.17, 0.45) 0.29 (0.15, 0.44)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.122 (0.095, 0.182) 0.142 (0.086, 0.405) 0.125 (0.087, 0.223) 0.135 (0.093, 0.359) 0.128 (0.084, 0.261) 0.141 (0.091, 0.335) 0.141 (0.09, 0.485) 0.153 (0.101, 0.487) 0.137 (0.082, 0.408) 0.165 (0.09, 0.511) 0.147 (0.09, 0.456) 0.123 (0.088, 0.394) 0.143 (0.084, 0.453) 0.144 (0.086, 0.357) 0.156 (0.08, 0.479) 0.157 (0.09, 0.416)
Niraparib count 79 79 79 79 79 79 79 79 79 79 79 79 79 79 79 79
time 29 (21, 35) 29 (21, 35) 29 (21, 35) 29 (21, 35) 29 (21, 35) 29 (21, 35) 29 (21, 35) 29 (21, 35) 29 (21, 35) 29 (21, 35) 29 (21, 35) 29 (21, 35) 29 (21, 35) 29 (21, 35) 29 (21, 35) 29 (21, 35)
n 19 (8, 58) 4 (1, 10) 11 (4, 37) 8 (3, 18) 6 (2, 12) 5 (3, 13) 4 (1, 9) 3 (1, 7) 5 (2, 10) 3 (1, 11) 4 (1, 10) 3 (2, 10) 4 (1, 8) 4 (1, 8) 4 (1, 7) 3 (2, 8)
post_p 0.16 (0.02, 0.39) 0.31 (0.12, 0.43) 0.14 (0.03, 0.4) 0.25 (0.08, 0.46) 0.29 (0.12, 0.46) 0.25 (0.08, 0.47) 0.34 (0.17, 0.48) 0.3 (0.16, 0.44) 0.29 (0.11, 0.46) 0.3 (0.12, 0.44) 0.29 (0.13, 0.46) 0.3 (0.17, 0.48) 0.3 (0.17, 0.46) 0.34 (0.16, 0.47) 0.3 (0.13, 0.46) 0.28 (0.14, 0.43)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.116 (0.089, 0.165) 0.147 (0.096, 0.492) 0.126 (0.091, 0.28) 0.123 (0.086, 0.286) 0.125 (0.091, 0.307) 0.136 (0.087, 0.349) 0.136 (0.076, 0.408) 0.176 (0.093, 0.465) 0.141 (0.084, 0.325) 0.17 (0.081, 0.559) 0.177 (0.088, 0.533) 0.141 (0.089, 0.387) 0.145 (0.086, 0.485) 0.141 (0.088, 0.555) 0.151 (0.089, 0.41) 0.182 (0.096, 0.773)
TP53- & AR- Hormone_therapies count 409 409 409 409
time 17 (9, 30) 17 (9, 30) 17 (9, 30) 17 (9, 30)
n 23 (16, 56) 6 (3, 14) 4 (1, 12) 4 (1, 12)
post_p 0.17 (0.02, 0.39) 0.33 (0.12, 0.47) 0.36 (0.18, 0.48) 0.37 (0.19, 0.48)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.116 (0.089, 0.159) 0.13 (0.081, 0.289) 0.134 (0.071, 0.554) 0.134 (0.074, 0.428)
Carboplatin count 390 390 390 390
time 21 (14, 31) 21 (14, 31) 21 (14, 31) 21 (14, 31)
n 20 (8, 60) 5 (2, 12) 7 (3, 16) 7 (3, 17)
post_p 0.19 (0.03, 0.45) 0.35 (0.15, 0.48) 0.32 (0.14, 0.47) 0.34 (0.12, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.112 (0.084, 0.182) 0.131 (0.077, 0.333) 0.128 (0.085, 0.289) 0.127 (0.085, 0.334)
Niraparib count 403 403 403 403
time 20 (13, 31) 20 (13, 31) 20 (13, 31) 20 (13, 31)
n 19 (8, 58) 5 (2, 14) 7 (3, 15) 6 (2, 15)
post_p 0.19 (0.03, 0.44) 0.36 (0.17, 0.47) 0.35 (0.15, 0.48) 0.32 (0.11, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.115 (0.086, 0.171) 0.131 (0.079, 0.412) 0.119 (0.078, 0.283) 0.133 (0.085, 0.358)
TP53+ Hormone_therapies count 229 229 229 229 229 229 229 229
time 24 (13, 34) 24 (13, 34) 24 (13, 34) 24 (13, 34) 24 (13, 34) 24 (13, 34) 24 (13, 34) 24 (13, 34)
n 14 (7, 44) 9 (4, 28) 3 (1, 9) 3 (0, 8) 4 (2, 12) 4 (2, 11) 3 (1, 8) 3 (1, 9)
post_p 0.18 (0.03, 0.43) 0.24 (0.07, 0.45) 0.35 (0.18, 0.48) 0.35 (0.17, 0.48) 0.33 (0.14, 0.47) 0.31 (0.15, 0.47) 0.34 (0.19, 0.47) 0.36 (0.17, 0.48)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.117 (0.088, 0.197) 0.122 (0.084, 0.251) 0.137 (0.074, 0.617) 0.154 (0.083, 0.607) 0.144 (0.084, 0.418) 0.13 (0.076, 0.48) 0.16 (0.078, 0.54) 0.145 (0.084, 0.44)
Carboplatin count 223 223 223 223 223 223 223 223
time 24 (14, 34) 24 (14, 34) 24 (14, 34) 24 (14, 34) 24 (14, 34) 24 (14, 34) 24 (14, 34) 24 (14, 34)
n 11 (5, 36) 9 (3, 25) 4 (2, 10) 4 (2, 9) 4 (1, 10) 4 (1, 11) 4 (1, 8) 4 (1, 8)
post_p 0.21 (0.04, 0.46) 0.27 (0.11, 0.46) 0.34 (0.17, 0.48) 0.35 (0.18, 0.48) 0.31 (0.13, 0.46) 0.35 (0.18, 0.47) 0.32 (0.18, 0.47) 0.32 (0.17, 0.45)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.122 (0.086, 0.248) 0.119 (0.087, 0.243) 0.138 (0.076, 0.403) 0.149 (0.086, 0.477) 0.149 (0.083, 0.53) 0.13 (0.08, 0.494) 0.158 (0.083, 0.535) 0.15 (0.088, 0.506)
Niraparib count 231 231 231 231 231 231 231 231
time 24 (15, 33) 24 (15, 33) 24 (15, 33) 24 (15, 33) 24 (15, 33) 24 (15, 33) 24 (15, 33) 24 (15, 33)
n 12 (4, 37) 8 (3, 19) 4 (1, 9) 4 (1, 8) 4 (1, 10) 3 (1, 10) 4 (2, 8) 3 (1, 9)
post_p 0.19 (0.06, 0.44) 0.25 (0.08, 0.46) 0.35 (0.17, 0.48) 0.33 (0.17, 0.47) 0.34 (0.14, 0.48) 0.33 (0.16, 0.47) 0.34 (0.15, 0.48) 0.31 (0.14, 0.47)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.121 (0.09, 0.25) 0.131 (0.086, 0.281) 0.136 (0.077, 0.384) 0.157 (0.082, 0.43) 0.145 (0.084, 0.437) 0.14 (0.081, 0.385) 0.145 (0.078, 0.334) 0.174 (0.093, 0.455)
DRD+ Hormone_therapies count 111 111 111 111 111 111 111 111
time 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35)
n 4 (1, 14) 4 (1, 11) 5 (1, 9) 4 (1, 9) 4 (1, 10) 4 (1, 9) 4 (1, 9) 4 (1, 8)
post_p 0.27 (0.11, 0.41) 0.28 (0.09, 0.45) 0.33 (0.16, 0.47) 0.34 (0.19, 0.46) 0.34 (0.17, 0.47) 0.34 (0.17, 0.47) 0.34 (0.17, 0.47) 0.32 (0.21, 0.46)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.148 (0.1, 0.596) 0.154 (0.084, 0.423) 0.136 (0.086, 0.497) 0.155 (0.084, 0.701) 0.14 (0.079, 0.564) 0.148 (0.081, 0.44) 0.149 (0.082, 0.517) 0.149 (0.09, 0.404)
Carboplatin count 183 183 183 183 183 183 183 183
time 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34)
n 7 (3, 17) 7 (2, 17) 4 (2, 10) 4 (1, 9) 3 (1, 9) 5 (1, 10) 4 (1, 9) 4 (1, 9)
post_p 0.28 (0.09, 0.47) 0.3 (0.11, 0.47) 0.34 (0.16, 0.48) 0.35 (0.16, 0.48) 0.32 (0.14, 0.48) 0.33 (0.14, 0.47) 0.31 (0.17, 0.45) 0.33 (0.15, 0.47)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.136 (0.088, 0.308) 0.129 (0.088, 0.288) 0.127 (0.078, 0.334) 0.152 (0.088, 0.477) 0.16 (0.083, 0.548) 0.131 (0.085, 0.347) 0.162 (0.081, 0.487) 0.149 (0.082, 0.47)
Niraparib count 175 175 175 175 175 175 175 175
time 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34)
n 7 (3, 13) 6 (2, 13) 4 (1, 9) 4 (1, 8) 4 (1, 9) 4 (1, 9) 4 (2, 9) 3 (1, 8)
post_p 0.3 (0.11, 0.46) 0.3 (0.1, 0.47) 0.34 (0.18, 0.47) 0.34 (0.17, 0.47) 0.32 (0.17, 0.48) 0.34 (0.16, 0.48) 0.33 (0.17, 0.47) 0.3 (0.16, 0.46)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.129 (0.087, 0.25) 0.139 (0.088, 0.37) 0.144 (0.082, 0.457) 0.151 (0.082, 0.521) 0.146 (0.087, 0.564) 0.147 (0.082, 0.517) 0.15 (0.079, 0.365) 0.17 (0.091, 0.483)
TEfus+ Hormone_therapies count 198 198 198 198 198 198 198 198
time 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34)
n 5 (3, 13) 11 (4, 25) 3 (1, 12) 3 (0, 8) 4 (2, 11) 4 (2, 10) 3 (1, 8) 3 (1, 8)
post_p 0.28 (0.1, 0.46) 0.27 (0.06, 0.46) 0.34 (0.16, 0.45) 0.36 (0.19, 0.48) 0.3 (0.13, 0.46) 0.28 (0.14, 0.47) 0.36 (0.19, 0.47) 0.35 (0.2, 0.47)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.138 (0.086, 0.302) 0.117 (0.079, 0.226) 0.15 (0.089, 0.419) 0.148 (0.079, 0.562) 0.145 (0.082, 0.372) 0.132 (0.087, 0.45) 0.141 (0.082, 0.415) 0.15 (0.081, 0.43)
Carboplatin count 191 191 191 191 191 191 191 191
time 25 (17, 34) 25 (17, 34) 25 (17, 34) 25 (17, 34) 25 (17, 34) 25 (17, 34) 25 (17, 34) 25 (17, 34)
n 5 (2, 13) 9 (3, 22) 7 (3, 17) 4 (2, 9) 4 (2, 10) 4 (1, 10) 4 (1, 9) 4 (1, 9)
post_p 0.31 (0.11, 0.48) 0.23 (0.06, 0.46) 0.32 (0.1, 0.47) 0.34 (0.17, 0.47) 0.33 (0.15, 0.47) 0.32 (0.17, 0.45) 0.32 (0.14, 0.46) 0.31 (0.16, 0.44)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.136 (0.078, 0.345) 0.127 (0.087, 0.26) 0.128 (0.08, 0.331) 0.146 (0.091, 0.477) 0.138 (0.08, 0.524) 0.133 (0.083, 0.454) 0.143 (0.086, 0.4) 0.15 (0.088, 0.505)
Niraparib count 209 209 209 209 209 209 209 209
time 23 (15, 35) 23 (15, 35) 23 (15, 35) 23 (15, 35) 23 (15, 35) 23 (15, 35) 23 (15, 35) 23 (15, 35)
n 4 (1, 11) 8 (3, 20) 6 (2, 14) 4 (1, 9) 4 (1, 10) 3 (1, 10) 4 (1, 9) 4 (2, 8)
post_p 0.31 (0.14, 0.47) 0.26 (0.1, 0.48) 0.3 (0.1, 0.47) 0.34 (0.17, 0.47) 0.31 (0.14, 0.46) 0.32 (0.16, 0.48) 0.33 (0.15, 0.48) 0.3 (0.14, 0.45)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.143 (0.086, 0.519) 0.127 (0.079, 0.271) 0.136 (0.08, 0.349) 0.15 (0.086, 0.434) 0.145 (0.076, 0.565) 0.149 (0.084, 0.38) 0.148 (0.082, 0.455) 0.163 (0.091, 0.473)