Simulation scenario 3

Setting description

Taxel_therapies more effective in all the biomarker signatures

Simulations setting

PFS distributions

Treatment effects

By subgroup:

subtype	var	Other	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
—-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
—+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
–+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
–++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
-+–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
-+-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
-++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
-+++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
+—	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
+–+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
+-+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
+-++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
++–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
++-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
+++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
++++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1

By signature:

signature	var	Other	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
TP53- & AR-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
TP53+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
DRD+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
TEfus+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1

Errors and power

graduation (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 3 264 0 1 TP53- & AR- 1 375 2 1 TP53+ 1 278 1 0 DRD+ 1 100 0 0 TEfus+ 0 260 1 1

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.006 0.528 0.000 0.002 TP53- & AR- 0.002 0.750 0.004 0.002 TP53+ 0.002 0.556 0.002 0.000 DRD+ 0.002 0.200 0.000 0.000 TEfus+ 0.000 0.520 0.002 0.002

futility (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 100 0 74 79 TP53- & AR- 409 0 390 403 TP53+ 229 0 223 231 DRD+ 111 0 183 175 TEfus+ 198 0 191 209

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.200 0 0.148 0.158 TP53- & AR- 0.818 0 0.780 0.806 TP53+ 0.458 0 0.446 0.462 DRD+ 0.222 0 0.366 0.350 TEfus+ 0.396 0 0.382 0.418

max sample size (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0 0 0 0 TP53- & AR- 5 14 30 17 TP53+ 19 77 24 22 DRD+ 0 0 0 0 TEfus+ 1 1 2 2

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.000 0.000 0.000 0.000 TP53- & AR- 0.010 0.028 0.060 0.034 TP53+ 0.038 0.154 0.048 0.044 DRD+ 0.000 0.000 0.000 0.000 TEfus+ 0.002 0.002 0.004 0.004

Errors & power

The overall error was 0.456.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.012             0.440             0.008             0.006 

The overall power was 0.528.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.000             0.528             0.000             0.000 

Median results at the end of the trial

By signature:

signature	var	Control	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	graduation	0	3	264	0	1
	futility	0	100	0	74	79
	max_n	0	0	0	0	0
	n	432 (352, 477)	139 (80, 225)	142 (49, 278)	155 (94, 249)	154 (89, 244)
	n_unique	401 (329, 445)	130 (74, 211)	132 (45, 259)	144 (87, 239)	144 (82, 231)
	time_trial	36 (36, 36)	36 (25, 36)	32 (8, 36)	36 (33, 36)	36 (31, 36)
	time_stop	NA (NA, NA)	25 (4, 35)	14 (6, 28)	30 (20, 36)	29 (20, 35)
	post_p	NA (NA, NA)	0 (0, 0.01)	1 (1, 1)	0 (0, 0.01)	0 (0, 0.01)
	rate	0.075 (0.069, 0.081)	0.114 (0.101, 0.131)	0.036 (0.031, 0.041)	0.113 (0.101, 0.129)	0.113 (0.102, 0.13)
TP53- & AR-	graduation	0	1	375	2	1
	futility	0	409	0	390	403
	max_n	0	5	14	30	17
	n	166 (99, 203)	39 (25, 105)	31 (18, 116)	47 (26, 136)	42 (25, 123)
	n_unique	155 (92, 191)	37 (23, 101)	29 (15, 111)	43 (24, 130)	40 (24, 118)
	time_trial	36 (36, 36)	19 (9, 36)	15 (9, 36)	23 (15, 36)	22 (13, 36)
	time_stop	NA (NA, NA)	17 (9, 30)	12 (9, 24)	21 (14, 31)	20 (13, 31)
	post_p	NA (NA, NA)	0.02 (0, 0.13)	1 (0.98, 1)	0.02 (0, 0.13)	0.02 (0, 0.14)
	rate	0.075 (0.066, 0.085)	0.117 (0.098, 0.151)	0.036 (0.027, 0.046)	0.114 (0.098, 0.145)	0.115 (0.098, 0.142)
TP53+	graduation	0	1	278	1	0
	futility	0	229	0	223	231
	max_n	0	19	77	24	22
	n	200 (173, 226)	66 (27, 120)	59 (25, 152)	71 (35, 127)	70 (32, 132)
	n_unique	188 (162, 210)	61 (26, 114)	56 (22, 143)	66 (32, 118)	65 (30, 123)
	time_trial	36 (36, 36)	36 (17, 36)	30 (9, 36)	36 (18, 36)	36 (17, 36)
	time_stop	NA (NA, NA)	24 (13, 34)	14 (8, 29)	24 (13, 34)	24 (15, 33)
	post_p	NA (NA, NA)	0.01 (0, 0.11)	1 (0.99, 1)	0.01 (0, 0.09)	0.01 (0, 0.09)
	rate	0.075 (0.067, 0.084)	0.114 (0.096, 0.142)	0.036 (0.029, 0.044)	0.114 (0.098, 0.137)	0.114 (0.099, 0.142)
DRD+	graduation	0	1	100	0	0
	futility	0	111	0	183	175
	max_n	0	0	0	0	0
	n	112 (90, 133)	41 (19, 69)	26 (5, 59)	55 (33, 80)	53 (29, 83)
	n_unique	105 (83, 123)	38 (17, 63)	24 (5, 56)	51 (30, 76)	49 (27, 78)
	time_trial	36 (36, 36)	36 (29, 36)	36 (24, 36)	36 (22, 36)	36 (20, 36)
	time_stop	NA (NA, NA)	30 (23, 35)	24 (16, 33)	26 (17, 34)	24 (16, 34)
	post_p	NA (NA, NA)	0.04 (0, 0.26)	1 (0.87, 1)	0.02 (0, 0.15)	0.02 (0, 0.16)
	rate	0.075 (0.064, 0.086)	0.114 (0.093, 0.156)	0.036 (0.023, 0.051)	0.116 (0.096, 0.141)	0.114 (0.096, 0.145)
TEfus+	graduation	0	0	260	1	1
	futility	0	198	0	191	209
	max_n	0	1	1	2	2
	n	155 (127, 178)	54 (25, 91)	43 (20, 103)	62 (33, 101)	59 (30, 105)
	n_unique	144 (118, 167)	50 (23, 85)	39 (18, 97)	57 (31, 95)	54 (27, 96)
	time_trial	36 (36, 36)	36 (21, 36)	33 (11, 36)	36 (20, 36)	36 (18, 36)
	time_stop	NA (NA, NA)	26 (17, 34)	15 (10, 29)	25 (17, 34)	23 (15, 35)
	post_p	NA (NA, NA)	0.02 (0, 0.16)	1 (0.99, 1)	0.02 (0, 0.15)	0.01 (0, 0.13)
	rate	0.075 (0.066, 0.085)	0.115 (0.096, 0.144)	0.037 (0.028, 0.045)	0.113 (0.096, 0.138)	0.115 (0.097, 0.145)

By subgroup combinations:

subtype	var	Control	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
—-	graduation	0	442	464	396	412
	futility	0	0	0	0	0
	max_n	0	5	14	30	17
	n	108 (63, 135)	23 (15, 67)	22 (10, 83)	24 (9, 86)	21 (8, 83)
	n_unique	101 (57, 127)	22 (14, 66)	21 (10, 80)	22 (8, 83)	20 (7, 79)
	post_p	NA (NA, NA)	0.06 (0, 0.26)	1 (0.92, 1)	0.08 (0, 0.3)	0.07 (0, 0.33)
	rate	0.075 (0.064, 0.087)	0.117 (0.093, 0.157)	0.035 (0.026, 0.049)	0.115 (0.093, 0.173)	0.115 (0.091, 0.173)
—+	graduation	0	457	469	410	429
	futility	0	0	0	0	0
	max_n	0	5	14	31	19
	n	18 (10, 27)	6 (2, 15)	5 (2, 12)	6 (2, 16)	5 (2, 17)
	n_unique	17 (9, 25)	5 (2, 14)	5 (2, 11)	5 (2, 16)	5 (1, 16)
	post_p	NA (NA, NA)	0.26 (0.09, 0.54)	0.87 (0.53, 0.99)	0.28 (0.11, 0.62)	0.28 (0.1, 0.58)
	rate	0.074 (0.05, 0.111)	0.134 (0.082, 0.304)	0.037 (0.017, 0.079)	0.126 (0.073, 0.283)	0.13 (0.076, 0.392)
–+-	graduation	0	260	360	227	234
	futility	0	0	0	0	0
	max_n	0	19	73	24	22
	n	69 (57, 83)	16 (7, 51)	22 (6, 63)	16 (5, 51)	15 (5, 52)
	n_unique	66 (54, 78)	15 (6, 49)	21 (5, 61)	15 (5, 49)	14 (5, 49)
	post_p	NA (NA, NA)	0.12 (0.02, 0.36)	1 (0.83, 1)	0.12 (0.03, 0.44)	0.13 (0.02, 0.41)
	rate	0.076 (0.062, 0.092)	0.12 (0.091, 0.196)	0.036 (0.023, 0.054)	0.121 (0.088, 0.211)	0.12 (0.089, 0.23)
–++	graduation	0	331	415	292	297
	futility	0	0	0	0	0
	max_n	0	19	71	25	23
	n	46 (33, 56)	12 (4, 33)	14 (6, 40)	11 (4, 33)	10 (4, 34)
	n_unique	43 (31, 54)	11 (3, 31)	13 (5, 37)	10 (3, 32)	9 (3, 32)
	post_p	NA (NA, NA)	0.19 (0.05, 0.47)	0.98 (0.76, 1)	0.2 (0.04, 0.51)	0.18 (0.04, 0.46)
	rate	0.076 (0.06, 0.096)	0.119 (0.084, 0.239)	0.038 (0.023, 0.058)	0.121 (0.082, 0.22)	0.125 (0.086, 0.241)
-+–	graduation	0	449	467	414	425
	futility	0	0	0	0	0
	max_n	0	5	14	30	17
	n	19 (10, 27)	4 (0, 14)	3 (0, 11)	8 (3, 20)	8 (3, 19)
	n_unique	17 (8, 26)	4 (0, 14)	2 (0, 10)	7 (3, 19)	7 (2, 18)
	post_p	NA (NA, NA)	0.3 (0.12, 0.57)	0.8 (0.48, 0.97)	0.27 (0.09, 0.54)	0.26 (0.09, 0.54)
	rate	0.074 (0.051, 0.107)	0.137 (0.077, 0.494)	0.039 (0.008, 0.091)	0.124 (0.079, 0.265)	0.121 (0.08, 0.244)
-+-+	graduation	0	465	472	423	438
	futility	0	0	0	0	0
	max_n	0	4	14	31	19
	n	17 (9, 27)	4 (0, 13)	3 (0, 9)	8 (3, 20)	6 (2, 19)
	n_unique	16 (8, 25)	4 (0, 13)	2 (0, 8)	8 (3, 19)	6 (2, 17)
	post_p	NA (NA, NA)	0.31 (0.14, 0.59)	0.82 (0.48, 0.98)	0.29 (0.1, 0.61)	0.27 (0.09, 0.59)
	rate	0.078 (0.051, 0.113)	0.136 (0.079, 0.411)	0.039 (0, 0.101)	0.12 (0.078, 0.29)	0.128 (0.082, 0.347)
-++-	graduation	0	286	381	281	280
	futility	0	0	0	0	0
	max_n	0	19	71	22	22
	n	13 (8, 18)	4 (1, 11)	2 (0, 9)	5 (2, 12)	5 (2, 12)
	n_unique	12 (7, 17)	4 (1, 10)	2 (0, 9)	5 (2, 12)	5 (1, 11)
	post_p	NA (NA, NA)	0.34 (0.16, 0.61)	0.77 (0.4, 0.95)	0.31 (0.14, 0.62)	0.32 (0.15, 0.6)
	rate	0.075 (0.048, 0.118)	0.127 (0.072, 0.395)	0.041 (0, 0.14)	0.127 (0.073, 0.316)	0.125 (0.07, 0.336)
-+++	graduation	0	342	423	327	326
	futility	0	0	0	0	0
	max_n	0	19	69	23	23
	n	12 (7, 17)	4 (0, 10)	2 (0, 7)	5 (2, 13)	5 (1, 13)
	n_unique	11 (6, 16)	3 (0, 10)	2 (0, 7)	5 (1, 12)	5 (1, 12)
	post_p	NA (NA, NA)	0.35 (0.16, 0.65)	0.77 (0.41, 0.95)	0.32 (0.14, 0.59)	0.32 (0.15, 0.66)
	rate	0.078 (0.046, 0.125)	0.132 (0.072, 0.494)	0.041 (0, 0.119)	0.134 (0.079, 0.39)	0.134 (0.073, 0.348)
+—	graduation	0	103	264	74	80
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	22 (15, 28)	5 (2, 16)	13 (3, 26)	6 (2, 15)	6 (2, 15)
	n_unique	20 (14, 27)	5 (2, 14)	12 (3, 24)	5 (2, 15)	5 (2, 14)
	post_p	NA (NA, NA)	0.26 (0.11, 0.57)	0.94 (0.64, 1)	0.28 (0.1, 0.58)	0.28 (0.11, 0.54)
	rate	0.076 (0.053, 0.106)	0.129 (0.075, 0.363)	0.035 (0.02, 0.065)	0.128 (0.073, 0.373)	0.128 (0.073, 0.313)
+–+	graduation	0	239	366	196	215
	futility	0	0	0	0	0
	max_n	0	1	1	2	2
	n	18 (12, 24)	5 (2, 14)	7 (2, 18)	5 (2, 14)	5 (2, 14)
	n_unique	16 (11, 23)	5 (1, 13)	6 (2, 17)	5 (2, 13)	5 (2, 13)
	post_p	NA (NA, NA)	0.29 (0.11, 0.59)	0.88 (0.55, 0.98)	0.3 (0.12, 0.58)	0.3 (0.12, 0.56)
	rate	0.075 (0.048, 0.117)	0.133 (0.07, 0.388)	0.038 (0.018, 0.075)	0.126 (0.071, 0.333)	0.129 (0.068, 0.389)
+-+-	graduation	0	260	360	227	234
	futility	0	0	0	0	0
	max_n	0	19	73	24	22
	n	18 (11, 24)	5 (1, 14)	6 (2, 18)	5 (2, 14)	6 (2, 15)
	n_unique	16 (11, 23)	5 (1, 13)	6 (2, 17)	5 (1, 13)	5 (2, 14)
	post_p	NA (NA, NA)	0.29 (0.13, 0.59)	0.88 (0.52, 0.99)	0.31 (0.12, 0.56)	0.29 (0.12, 0.6)
	rate	0.074 (0.051, 0.114)	0.132 (0.068, 0.385)	0.038 (0.017, 0.088)	0.126 (0.074, 0.424)	0.127 (0.068, 0.348)
+-++	graduation	0	331	415	292	297
	futility	0	0	0	0	0
	max_n	0	19	71	25	23
	n	17 (12, 23)	5 (2, 14)	5 (2, 15)	6 (2, 15)	5 (2, 13)
	n_unique	16 (10, 22)	4 (1, 12)	5 (1, 15)	5 (1, 14)	5 (2, 13)
	post_p	NA (NA, NA)	0.3 (0.12, 0.57)	0.88 (0.55, 0.98)	0.31 (0.13, 0.62)	0.3 (0.12, 0.59)
	rate	0.075 (0.048, 0.111)	0.125 (0.073, 0.39)	0.036 (0.016, 0.074)	0.122 (0.073, 0.355)	0.129 (0.073, 0.344)
++–	graduation	0	167	303	187	182
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	13 (8, 18)	4 (1, 11)	4 (0, 12)	5 (2, 12)	5 (2, 11)
	n_unique	12 (7, 17)	4 (1, 10)	4 (0, 11)	4 (2, 11)	4 (2, 10)
	post_p	NA (NA, NA)	0.35 (0.16, 0.64)	0.8 (0.45, 0.97)	0.32 (0.14, 0.6)	0.32 (0.14, 0.59)
	rate	0.075 (0.044, 0.12)	0.126 (0.064, 0.421)	0.038 (0.003, 0.107)	0.13 (0.076, 0.382)	0.128 (0.071, 0.415)
++-+	graduation	0	276	389	260	272
	futility	0	0	0	0	0
	max_n	0	0	1	2	2
	n	12 (7, 19)	4 (1, 11)	2 (0, 10)	5 (2, 11)	5 (2, 13)
	n_unique	12 (7, 17)	4 (1, 10)	2 (0, 9)	5 (1, 11)	5 (1, 12)
	post_p	NA (NA, NA)	0.34 (0.16, 0.65)	0.81 (0.43, 0.97)	0.32 (0.14, 0.61)	0.33 (0.13, 0.63)
	rate	0.077 (0.046, 0.13)	0.132 (0.068, 0.359)	0.039 (0, 0.127)	0.128 (0.076, 0.411)	0.129 (0.072, 0.377)
+++-	graduation	0	286	381	281	280
	futility	0	0	0	0	0
	max_n	0	19	71	22	22
	n	13 (8, 18)	4 (1, 11)	2 (0, 9)	5 (1, 12)	5 (2, 12)
	n_unique	11 (7, 17)	4 (1, 10)	2 (0, 9)	5 (1, 12)	5 (2, 11)
	post_p	NA (NA, NA)	0.34 (0.15, 0.63)	0.8 (0.45, 0.96)	0.31 (0.13, 0.59)	0.33 (0.15, 0.6)
	rate	0.076 (0.048, 0.126)	0.13 (0.068, 0.421)	0.035 (0, 0.114)	0.133 (0.076, 0.396)	0.127 (0.075, 0.302)
++++	graduation	0	342	423	327	326
	futility	0	0	0	0	0
	max_n	0	19	69	23	23
	n	12 (7, 17)	4 (1, 11)	2 (0, 7)	5 (2, 13)	5 (2, 12)
	n_unique	11 (7, 16)	4 (0, 10)	2 (0, 7)	5 (1, 12)	5 (1, 11)
	post_p	NA (NA, NA)	0.35 (0.16, 0.66)	0.78 (0.42, 0.96)	0.32 (0.14, 0.62)	0.31 (0.14, 0.62)
	rate	0.076 (0.046, 0.125)	0.135 (0.068, 0.371)	0.04 (0, 0.138)	0.13 (0.072, 0.407)	0.136 (0.073, 0.362)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	count	3	264		1
	time_stop	3 (3, 5)	14 (6, 28)		7 (7, 7)
	n_trt	27 (27, 34)	86 (37, 202)		31 (31, 31)
	n_control	34 (34, 56)	146 (65, 327)		75 (75, 75)
	post_p	0.94 (0.9, 0.95)	1 (0.98, 1)		0.88 (0.88, 0.88)
	order	1 (1, 1)	2 (1, 3)		1 (1, 1)
TP53- & AR-	count	1	375	2	1
	time_stop	13 (13, 13)	12 (9, 24)	12 (12, 13)	15 (15, 15)
	n_trt	32 (32, 32)	33 (25, 83)	30 (26, 33)	26 (26, 26)
	n_control	64 (64, 64)	53 (35, 118)	60 (58, 62)	74 (74, 74)
	post_p	0.88 (0.88, 0.88)	0.98 (0.91, 1)	0.93 (0.92, 0.94)	0.97 (0.97, 0.97)
	order	3 (3, 3)	1 (1, 3)	4 (4, 4)	4 (4, 4)
TP53+	count	1	278	1
	time_stop	7 (7, 7)	14 (8, 29)	10 (10, 10)
	n_trt	26 (26, 26)	44 (27, 113)	27 (27, 27)
	n_control	26 (26, 26)	64 (36, 156)	51 (51, 51)
	post_p	0.93 (0.93, 0.93)	1 (0.95, 1)	0.92 (0.92, 0.92)
	order	1 (1, 1)	2 (1, 4)	1 (1, 1)
DRD+	count	1	100
	time_stop	15 (15, 15)	24 (16, 33)
	n_trt	26 (26, 26)	30 (25, 55)
	n_control	41 (41, 41)	66 (41, 101)
	post_p	0.86 (0.86, 0.86)	1 (0.98, 1)
	order	5 (5, 5)	3 (1, 5)
TEfus+	count		260	1	1
	time_stop		15 (10, 29)	10 (10, 10)	12 (12, 12)
	n_trt		38 (26, 77)	26 (26, 26)	25 (25, 25)
	n_control		60 (35, 126)	42 (42, 42)	49 (49, 49)
	post_p		1 (0.97, 1)	0.91 (0.91, 0.91)	0.95 (0.95, 0.95)
	order		2 (1, 4)	2 (2, 2)	2 (2, 2)

Futility:

signature	var	Hormone_therapies	Carboplatin	Niraparib
all	count	100	74	79
	time_stop	26 (4, 35)	30 (20, 36)	29 (21, 35)
	n_trt	88 (28, 167)	116 (80, 197)	106 (72, 173)
	n_control	281 (38, 419)	333 (225, 429)	321 (223, 410)
	post_p	0 (0, 0.11)	0 (0, 0.01)	0 (0, 0)
	order	5.5 (1, 9)	6 (3.3, 9)	6 (3, 9)
TP53- & AR-	count	409	390	403
	time_stop	17 (9, 30)	21 (14, 31)	20 (13, 31)
	n_trt	37 (25, 87)	40 (25, 93)	37 (25, 93)
	n_control	75 (36, 149)	102 (60, 162)	96 (55, 162)
	post_p	0.07 (0, 0.23)	0.06 (0, 0.19)	0.06 (0, 0.2)
	order	2 (1, 5)	3 (1, 6)	3 (1, 6)
TP53+	count	229	223	231
	time_stop	24 (13, 34)	24 (14, 34)	24 (15, 33)
	n_trt	49 (28, 109)	49 (28, 95)	49 (27, 89)
	n_control	129 (58, 194)	130 (63, 190)	123 (66, 185)
	post_p	0.01 (0, 0.09)	0.01 (0, 0.08)	0.01 (0, 0.07)
	order	4 (1, 8)	4 (1, 7)	4 (1, 8)
DRD+	count	111	183	175
	time_stop	30 (23, 35)	26 (17, 34)	24 (16, 34)
	n_trt	37 (26, 58)	43 (29, 67)	39 (27, 57)
	n_control	93 (67, 123)	82 (49, 111)	73 (43, 110)
	post_p	0.01 (0, 0.06)	0.01 (0, 0.07)	0.01 (0, 0.08)
	order	6 (3, 9)	5 (2, 8)	4 (2, 9)
TEfus+	count	198	191	209
	time_stop	26 (17, 34)	25 (17, 34)	23 (15, 35)
	n_trt	44 (26, 74)	47 (29, 75)	41 (26, 70)
	n_control	108 (64, 153)	107 (69, 149)	98 (59, 152)
	post_p	0.02 (0, 0.08)	0.01 (0, 0.07)	0.01 (0, 0.06)
	order	5 (2, 9)	5 (2, 9)	5 (2, 8)

By subgroup combinations

Graduation:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Hormone_therapies	count	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3
		time	3 (3, 5)	3 (3, 5)	3 (3, 5)	3 (3, 5)	3 (3, 5)	3 (3, 5)	3 (3, 5)	3 (3, 5)	3 (3, 5)	3 (3, 5)	3 (3, 5)	3 (3, 5)	3 (3, 5)	3 (3, 5)	3 (3, 5)	3 (3, 5)
		n	14 (12, 16)	2 (2, 2)	8 (7, 9)	2 (1, 3)	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 2)	0 (0, 1)	0 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 2)	0 (0, 0)
		post_p	0.63 (0.58, 0.73)	0.54 (0.52, 0.56)	0.63 (0.55, 0.7)	0.6 (0.58, 0.61)	0.58 (0.58, 0.58)	0.53 (0.53, 0.53)	NA (NA, NA)	NA (NA, NA)	0.61 (0.61, 0.61)	0.64 (0.64, 0.64)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.53 (0.53, 0.53)	NA (NA, NA)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.076 (0.05, 0.083)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)
	Taxel_therapies	count	264	264	264	264	264	264	264	264	264	264	264	264	264	264	264	264
		time	14 (6, 28)	14 (6, 28)	14 (6, 28)	14 (6, 28)	14 (6, 28)	14 (6, 28)	14 (6, 28)	14 (6, 28)	14 (6, 28)	14 (6, 28)	14 (6, 28)	14 (6, 28)	14 (6, 28)	14 (6, 28)	14 (6, 28)	14 (6, 28)
		n	19 (7, 46)	4 (2, 10)	13 (4, 41)	12 (5, 27)	2 (0, 7)	2 (0, 6)	2 (0, 6)	1 (0, 5)	7 (2, 16)	5 (2, 12)	4 (1, 10)	4 (1, 10)	2 (0, 6)	1 (0, 6)	1 (0, 6)	1 (0, 5)
		post_p	0.92 (0.62, 1)	0.74 (0.55, 0.95)	0.85 (0.58, 1)	0.8 (0.57, 0.98)	0.66 (0.52, 0.89)	0.68 (0.53, 0.88)	0.66 (0.54, 0.86)	0.63 (0.52, 0.85)	0.75 (0.54, 0.97)	0.68 (0.53, 0.93)	0.67 (0.53, 0.89)	0.69 (0.53, 0.92)	0.64 (0.52, 0.87)	0.64 (0.52, 0.89)	0.63 (0.51, 0.9)	0.66 (0.52, 0.88)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)	0.17 (0.17, 0.17)	0.41 (0.41, 0.41)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.41 (0.41, 0.41)	0.37 (0.37, 0.37)	0.37 (0.37, 0.37)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.033 (0, 0.058)	0.022 (0, 0.072)	0.032 (0, 0.063)	0.035 (0, 0.065)	0 (0, 0.068)	0 (0, 0.075)	0 (0, 0.064)	0 (0, 0.084)	0.028 (0, 0.062)	0.022 (0, 0.069)	0.029 (0, 0.074)	0.023 (0, 0.08)	0 (0, 0.076)	0 (0, 0.071)	0 (0, 0.074)	0 (0, 0.061)
	Niraparib	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
		time	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)
		n	7 (7, 7)	1 (1, 1)	5 (5, 5)	1 (1, 1)	2 (2, 2)	2 (2, 2)	2 (2, 2)	0 (0, 0)	0 (0, 0)	1 (1, 1)	5 (5, 5)	0 (0, 0)	3 (3, 3)	1 (1, 1)	0 (0, 0)	1 (1, 1)
		post_p	0.5 (0.5, 0.5)	0.51 (0.51, 0.51)	0.55 (0.55, 0.55)	0.54 (0.54, 0.54)	0.64 (0.64, 0.64)	0.69 (0.69, 0.69)	0.61 (0.61, 0.61)	NA (NA, NA)	NA (NA, NA)	0.56 (0.56, 0.56)	0.57 (0.57, 0.57)	NA (NA, NA)	0.62 (0.62, 0.62)	0.57 (0.57, 0.57)	NA (NA, NA)	0.58 (0.58, 0.58)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.074 (0.074, 0.074)	0 (0, 0)	0.059 (0.059, 0.059)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0.081 (0.081, 0.081)	0 (0, 0)	NA (NA, NA)	0 (0, 0)
TP53- & AR-	Hormone_therapies	count	1	1			1	1
		time	13 (13, 13)	13 (13, 13)			13 (13, 13)	13 (13, 13)
		n	23 (23, 23)	5 (5, 5)			4 (4, 4)	0 (0, 0)
		post_p	0.83 (0.83, 0.83)	0.54 (0.54, 0.54)			0.56 (0.56, 0.56)	NA (NA, NA)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.074 (0.074, 0.074)	0.059 (0.059, 0.059)			0.071 (0.071, 0.071)	NA (NA, NA)
	Taxel_therapies	count	375	375			375	375
		time	12 (9, 24)	12 (9, 24)			12 (9, 24)	12 (9, 24)
		n	23 (16, 59)	5 (2, 11)			3 (1, 9)	3 (0, 8)
		post_p	0.92 (0.76, 1)	0.74 (0.55, 0.91)			0.64 (0.52, 0.86)	0.64 (0.52, 0.89)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.032 (0.014, 0.051)	0.026 (0, 0.071)			0 (0, 0.074)	0 (0, 0.08)
	Carboplatin	count	2	2			2	2
		time	12 (12, 13)	12 (12, 13)			12 (12, 13)	12 (12, 13)
		n	14 (9, 19)	2 (2, 3)			4 (3, 5)	9 (7, 11)
		post_p	0.79 (0.76, 0.81)	0.56 (0.54, 0.59)			0.57 (0.52, 0.61)	0.79 (0.74, 0.85)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.022 (0.004, 0.04)	0 (0, 0)			0.082 (0.056, 0.109)	0.039 (0.037, 0.041)
	Niraparib	count	1	1			1	1
		time	15 (15, 15)	15 (15, 15)			15 (15, 15)	15 (15, 15)
		n	16 (16, 16)	1 (1, 1)			5 (5, 5)	4 (4, 4)
		post_p	0.78 (0.78, 0.78)	0.54 (0.54, 0.54)			0.84 (0.84, 0.84)	0.53 (0.53, 0.53)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.053 (0.053, 0.053)	0 (0, 0)			0 (0, 0)	0.072 (0.072, 0.072)
TP53+	Hormone_therapies	count			1	1			1	1			1	1			1	1
		time			7 (7, 7)	7 (7, 7)			7 (7, 7)	7 (7, 7)			7 (7, 7)	7 (7, 7)			7 (7, 7)	7 (7, 7)
		n			16 (16, 16)	4 (4, 4)			1 (1, 1)	0 (0, 0)			2 (2, 2)	3 (3, 3)			0 (0, 0)	0 (0, 0)
		post_p			0.84 (0.84, 0.84)	0.6 (0.6, 0.6)			0.58 (0.58, 0.58)	NA (NA, NA)			0.63 (0.63, 0.63)	0.53 (0.53, 0.53)			NA (NA, NA)	NA (NA, NA)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.031 (0.031, 0.031)	0.064 (0.064, 0.064)			0 (0, 0)	NA (NA, NA)			0 (0, 0)	0 (0, 0)			NA (NA, NA)	NA (NA, NA)
	Taxel_therapies	count			278	278			278	278			278	278			278	278
		time			14 (8, 29)	14 (8, 29)			14 (8, 29)	14 (8, 29)			14 (8, 29)	14 (8, 29)			14 (8, 29)	14 (8, 29)
		n			16 (7, 47)	13 (7, 27)			2 (0, 6)	1 (0, 5)			5 (2, 12)	4 (2, 12)			2 (0, 6)	2 (0, 6)
		post_p			0.89 (0.72, 1)	0.85 (0.71, 0.99)			0.64 (0.52, 0.87)	0.63 (0.52, 0.86)			0.73 (0.53, 0.92)	0.75 (0.54, 0.94)			0.63 (0.52, 0.92)	0.68 (0.52, 0.89)
		r_prob			0.17 (0.17, 0.17)	0.41 (0.41, 0.41)			0 (0, 0)	0 (0, 0)			0.37 (0.37, 0.37)	0.37 (0.37, 0.37)			0 (0, 0)	0 (0, 0)
		rate			0.033 (0, 0.058)	0.036 (0.011, 0.062)			0 (0, 0.073)	0 (0, 0.071)			0.032 (0, 0.079)	0.024 (0, 0.072)			0 (0, 0.063)	0 (0, 0.072)
	Carboplatin	count			1	1			1	1			1	1			1	1
		time			10 (10, 10)	10 (10, 10)			10 (10, 10)	10 (10, 10)			10 (10, 10)	10 (10, 10)			10 (10, 10)	10 (10, 10)
		n			7 (7, 7)	4 (4, 4)			0 (0, 0)	3 (3, 3)			4 (4, 4)	2 (2, 2)			3 (3, 3)	4 (4, 4)
		post_p			0.77 (0.77, 0.77)	0.76 (0.76, 0.76)			NA (NA, NA)	0.56 (0.56, 0.56)			0.57 (0.57, 0.57)	0.57 (0.57, 0.57)			0.61 (0.61, 0.61)	0.7 (0.7, 0.7)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.062 (0.062, 0.062)	0 (0, 0)			NA (NA, NA)	0.095 (0.095, 0.095)			0.047 (0.047, 0.047)	0 (0, 0)			0 (0, 0)	0.101 (0.101, 0.101)
DRD+	Hormone_therapies	count					1	1	1	1					1	1	1	1
		time					15 (15, 15)	15 (15, 15)	15 (15, 15)	15 (15, 15)					15 (15, 15)	15 (15, 15)	15 (15, 15)	15 (15, 15)
		n					9 (9, 9)	0 (0, 0)	1 (1, 1)	3 (3, 3)					2 (2, 2)	3 (3, 3)	2 (2, 2)	6 (6, 6)
		post_p					0.71 (0.71, 0.71)	NA (NA, NA)	0.52 (0.52, 0.52)	0.52 (0.52, 0.52)					0.52 (0.52, 0.52)	0.71 (0.71, 0.71)	0.56 (0.56, 0.56)	0.72 (0.72, 0.72)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.055 (0.055, 0.055)	NA (NA, NA)	0 (0, 0)	0 (0, 0)					0.092 (0.092, 0.092)	0.065 (0.065, 0.065)	0.083 (0.083, 0.083)	0.084 (0.084, 0.084)
	Taxel_therapies	count					100	100	100	100					100	100	100	100
		time					24 (16, 33)	24 (16, 33)	24 (16, 33)	24 (16, 33)					24 (16, 33)	24 (16, 33)	24 (16, 33)	24 (16, 33)
		n					4 (1, 11)	4 (1, 11)	4 (1, 9)	2 (0, 7)					4 (1, 10)	3 (1, 8)	3 (0, 9)	3 (0, 7)
		post_p					0.77 (0.6, 0.94)	0.77 (0.58, 0.94)	0.74 (0.53, 0.93)	0.73 (0.53, 0.89)					0.73 (0.52, 0.93)	0.75 (0.55, 0.95)	0.75 (0.53, 0.92)	0.72 (0.54, 0.9)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.034 (0, 0.069)	0.034 (0, 0.075)	0.026 (0, 0.09)	0.032 (0, 0.089)					0.02 (0, 0.076)	0.019 (0, 0.061)	0.016 (0, 0.083)	0.03 (0, 0.078)
TEfus+		count		260		260		260		260		260		260		260		260
		time		15 (10, 29)		15 (10, 29)		15 (10, 29)		15 (10, 29)		15 (10, 29)		15 (10, 29)		15 (10, 29)		15 (10, 29)
		n		5 (2, 11)		14 (8, 28)		2 (0, 6)		2 (0, 5)		5 (2, 12)		5 (2, 11)		2 (0, 7)		2 (0, 5)
		post_p		0.77 (0.57, 0.95)		0.86 (0.73, 1)		0.7 (0.53, 0.89)		0.66 (0.52, 0.88)		0.74 (0.54, 0.93)		0.77 (0.55, 0.93)		0.67 (0.52, 0.92)		0.66 (0.53, 0.87)
		r_prob		0.29 (0.29, 0.29)		0.41 (0.41, 0.41)		0 (0, 0)		0 (0, 0)		0.41 (0.41, 0.41)		0.37 (0.37, 0.37)		0 (0, 0)		0 (0, 0)
		rate		0.027 (0, 0.064)		0.035 (0.014, 0.063)		0 (0, 0.079)		0 (0, 0.08)		0.031 (0, 0.069)		0.028 (0, 0.071)		0 (0, 0.069)		0 (0, 0.076)
	Carboplatin	count		1		1		1		1		1		1		1		1
		time		10 (10, 10)		10 (10, 10)		10 (10, 10)		10 (10, 10)		10 (10, 10)		10 (10, 10)		10 (10, 10)		10 (10, 10)
		n		3 (3, 3)		3 (3, 3)		5 (5, 5)		1 (1, 1)		3 (3, 3)		3 (3, 3)		4 (4, 4)		4 (4, 4)
		post_p		0.66 (0.66, 0.66)		0.62 (0.62, 0.62)		0.69 (0.69, 0.69)		0.68 (0.68, 0.68)		0.61 (0.61, 0.61)		0.52 (0.52, 0.52)		0.72 (0.72, 0.72)		0.7 (0.7, 0.7)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0 (0, 0)		0 (0, 0)		0.116 (0.116, 0.116)		0 (0, 0)		0 (0, 0)		0.086 (0.086, 0.086)		0.075 (0.075, 0.075)		0 (0, 0)
	Niraparib	count		1		1		1		1		1		1		1		1
		time		12 (12, 12)		12 (12, 12)		12 (12, 12)		12 (12, 12)		12 (12, 12)		12 (12, 12)		12 (12, 12)		12 (12, 12)
		n		2 (2, 2)		4 (4, 4)		5 (5, 5)		2 (2, 2)		0 (0, 0)		4 (4, 4)		4 (4, 4)		4 (4, 4)
		post_p		0.54 (0.54, 0.54)		0.67 (0.67, 0.67)		0.66 (0.66, 0.66)		0.54 (0.54, 0.54)		NA (NA, NA)		0.63 (0.63, 0.63)		0.71 (0.71, 0.71)		0.58 (0.58, 0.58)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0 (0, 0)		0 (0, 0)		0.042 (0.042, 0.042)		0 (0, 0)		NA (NA, NA)		0 (0, 0)		0.046 (0.046, 0.046)		0.038 (0.038, 0.038)

Futility:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Hormone_therapies	count	100	100	100	100	100	100	100	100	100	100	100	100	100	100	100	100
		time	26 (4, 35)	26 (4, 35)	26 (4, 35)	26 (4, 35)	26 (4, 35)	26 (4, 35)	26 (4, 35)	26 (4, 35)	26 (4, 35)	26 (4, 35)	26 (4, 35)	26 (4, 35)	26 (4, 35)	26 (4, 35)	26 (4, 35)	26 (4, 35)
		n	20 (13, 44)	4 (1, 8)	10 (5, 32)	6 (2, 26)	2 (0, 7)	2 (0, 9)	2 (0, 8)	2 (0, 7)	4 (0, 12)	3 (1, 10)	3 (0, 10)	3 (0, 9)	2 (0, 7)	2 (0, 7)	2 (0, 7)	2 (0, 7)
		post_p	0.13 (0.01, 0.41)	0.3 (0.13, 0.45)	0.19 (0.04, 0.43)	0.28 (0.05, 0.46)	0.31 (0.11, 0.42)	0.35 (0.12, 0.46)	0.33 (0.16, 0.47)	0.34 (0.19, 0.48)	0.3 (0.12, 0.45)	0.3 (0.18, 0.48)	0.3 (0.13, 0.47)	0.28 (0.16, 0.46)	0.34 (0.18, 0.45)	0.32 (0.16, 0.49)	0.33 (0.19, 0.44)	0.35 (0.21, 0.47)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.115 (0.088, 0.16)	0.161 (0.079, 0.455)	0.129 (0.082, 0.248)	0.127 (0.081, 0.396)	0.154 (0.083, 0.556)	0.16 (0.07, 0.384)	0.132 (0.072, 0.436)	0.165 (0.08, 0.537)	0.133 (0.068, 0.411)	0.156 (0.063, 0.607)	0.152 (0.086, 0.548)	0.155 (0.087, 0.451)	0.153 (0.076, 0.606)	0.149 (0.085, 0.693)	0.158 (0.081, 0.522)	0.146 (0.092, 0.516)
	Carboplatin	count	74	74	74	74	74	74	74	74	74	74	74	74	74	74	74	74
		time	30 (20, 36)	30 (20, 36)	30 (20, 36)	30 (20, 36)	30 (20, 36)	30 (20, 36)	30 (20, 36)	30 (20, 36)	30 (20, 36)	30 (20, 36)	30 (20, 36)	30 (20, 36)	30 (20, 36)	30 (20, 36)	30 (20, 36)	30 (20, 36)
		n	21 (9, 63)	5 (2, 15)	12 (5, 39)	8 (3, 19)	7 (3, 17)	7 (2, 17)	4 (1, 9)	4 (1, 8)	4 (2, 12)	4 (1, 11)	3 (1, 9)	4 (1, 11)	4 (2, 9)	4 (1, 10)	4 (1, 8)	4 (2, 8)
		post_p	0.1 (0.01, 0.36)	0.29 (0.12, 0.47)	0.19 (0.05, 0.43)	0.19 (0.06, 0.42)	0.27 (0.12, 0.47)	0.29 (0.1, 0.47)	0.33 (0.18, 0.48)	0.31 (0.15, 0.46)	0.28 (0.11, 0.44)	0.29 (0.16, 0.43)	0.29 (0.16, 0.45)	0.32 (0.15, 0.45)	0.32 (0.17, 0.46)	0.32 (0.12, 0.47)	0.29 (0.17, 0.45)	0.29 (0.15, 0.44)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.122 (0.095, 0.182)	0.142 (0.086, 0.405)	0.125 (0.087, 0.223)	0.135 (0.093, 0.359)	0.128 (0.084, 0.261)	0.141 (0.091, 0.335)	0.141 (0.09, 0.485)	0.153 (0.101, 0.487)	0.137 (0.082, 0.408)	0.165 (0.09, 0.511)	0.147 (0.09, 0.456)	0.123 (0.088, 0.394)	0.143 (0.084, 0.453)	0.144 (0.086, 0.357)	0.156 (0.08, 0.479)	0.157 (0.09, 0.416)
	Niraparib	count	79	79	79	79	79	79	79	79	79	79	79	79	79	79	79	79
		time	29 (21, 35)	29 (21, 35)	29 (21, 35)	29 (21, 35)	29 (21, 35)	29 (21, 35)	29 (21, 35)	29 (21, 35)	29 (21, 35)	29 (21, 35)	29 (21, 35)	29 (21, 35)	29 (21, 35)	29 (21, 35)	29 (21, 35)	29 (21, 35)
		n	19 (8, 58)	4 (1, 10)	11 (4, 37)	8 (3, 18)	6 (2, 12)	5 (3, 13)	4 (1, 9)	3 (1, 7)	5 (2, 10)	3 (1, 11)	4 (1, 10)	3 (2, 10)	4 (1, 8)	4 (1, 8)	4 (1, 7)	3 (2, 8)
		post_p	0.16 (0.02, 0.39)	0.31 (0.12, 0.43)	0.14 (0.03, 0.4)	0.25 (0.08, 0.46)	0.29 (0.12, 0.46)	0.25 (0.08, 0.47)	0.34 (0.17, 0.48)	0.3 (0.16, 0.44)	0.29 (0.11, 0.46)	0.3 (0.12, 0.44)	0.29 (0.13, 0.46)	0.3 (0.17, 0.48)	0.3 (0.17, 0.46)	0.34 (0.16, 0.47)	0.3 (0.13, 0.46)	0.28 (0.14, 0.43)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.116 (0.089, 0.165)	0.147 (0.096, 0.492)	0.126 (0.091, 0.28)	0.123 (0.086, 0.286)	0.125 (0.091, 0.307)	0.136 (0.087, 0.349)	0.136 (0.076, 0.408)	0.176 (0.093, 0.465)	0.141 (0.084, 0.325)	0.17 (0.081, 0.559)	0.177 (0.088, 0.533)	0.141 (0.089, 0.387)	0.145 (0.086, 0.485)	0.141 (0.088, 0.555)	0.151 (0.089, 0.41)	0.182 (0.096, 0.773)
TP53- & AR-	Hormone_therapies	count	409	409			409	409
		time	17 (9, 30)	17 (9, 30)			17 (9, 30)	17 (9, 30)
		n	23 (16, 56)	6 (3, 14)			4 (1, 12)	4 (1, 12)
		post_p	0.17 (0.02, 0.39)	0.33 (0.12, 0.47)			0.36 (0.18, 0.48)	0.37 (0.19, 0.48)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.116 (0.089, 0.159)	0.13 (0.081, 0.289)			0.134 (0.071, 0.554)	0.134 (0.074, 0.428)
	Carboplatin	count	390	390			390	390
		time	21 (14, 31)	21 (14, 31)			21 (14, 31)	21 (14, 31)
		n	20 (8, 60)	5 (2, 12)			7 (3, 16)	7 (3, 17)
		post_p	0.19 (0.03, 0.45)	0.35 (0.15, 0.48)			0.32 (0.14, 0.47)	0.34 (0.12, 0.48)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.112 (0.084, 0.182)	0.131 (0.077, 0.333)			0.128 (0.085, 0.289)	0.127 (0.085, 0.334)
	Niraparib	count	403	403			403	403
		time	20 (13, 31)	20 (13, 31)			20 (13, 31)	20 (13, 31)
		n	19 (8, 58)	5 (2, 14)			7 (3, 15)	6 (2, 15)
		post_p	0.19 (0.03, 0.44)	0.36 (0.17, 0.47)			0.35 (0.15, 0.48)	0.32 (0.11, 0.48)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.115 (0.086, 0.171)	0.131 (0.079, 0.412)			0.119 (0.078, 0.283)	0.133 (0.085, 0.358)
TP53+	Hormone_therapies	count			229	229			229	229			229	229			229	229
		time			24 (13, 34)	24 (13, 34)			24 (13, 34)	24 (13, 34)			24 (13, 34)	24 (13, 34)			24 (13, 34)	24 (13, 34)
		n			14 (7, 44)	9 (4, 28)			3 (1, 9)	3 (0, 8)			4 (2, 12)	4 (2, 11)			3 (1, 8)	3 (1, 9)
		post_p			0.18 (0.03, 0.43)	0.24 (0.07, 0.45)			0.35 (0.18, 0.48)	0.35 (0.17, 0.48)			0.33 (0.14, 0.47)	0.31 (0.15, 0.47)			0.34 (0.19, 0.47)	0.36 (0.17, 0.48)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.117 (0.088, 0.197)	0.122 (0.084, 0.251)			0.137 (0.074, 0.617)	0.154 (0.083, 0.607)			0.144 (0.084, 0.418)	0.13 (0.076, 0.48)			0.16 (0.078, 0.54)	0.145 (0.084, 0.44)
	Carboplatin	count			223	223			223	223			223	223			223	223
		time			24 (14, 34)	24 (14, 34)			24 (14, 34)	24 (14, 34)			24 (14, 34)	24 (14, 34)			24 (14, 34)	24 (14, 34)
		n			11 (5, 36)	9 (3, 25)			4 (2, 10)	4 (2, 9)			4 (1, 10)	4 (1, 11)			4 (1, 8)	4 (1, 8)
		post_p			0.21 (0.04, 0.46)	0.27 (0.11, 0.46)			0.34 (0.17, 0.48)	0.35 (0.18, 0.48)			0.31 (0.13, 0.46)	0.35 (0.18, 0.47)			0.32 (0.18, 0.47)	0.32 (0.17, 0.45)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.122 (0.086, 0.248)	0.119 (0.087, 0.243)			0.138 (0.076, 0.403)	0.149 (0.086, 0.477)			0.149 (0.083, 0.53)	0.13 (0.08, 0.494)			0.158 (0.083, 0.535)	0.15 (0.088, 0.506)
	Niraparib	count			231	231			231	231			231	231			231	231
		time			24 (15, 33)	24 (15, 33)			24 (15, 33)	24 (15, 33)			24 (15, 33)	24 (15, 33)			24 (15, 33)	24 (15, 33)
		n			12 (4, 37)	8 (3, 19)			4 (1, 9)	4 (1, 8)			4 (1, 10)	3 (1, 10)			4 (2, 8)	3 (1, 9)
		post_p			0.19 (0.06, 0.44)	0.25 (0.08, 0.46)			0.35 (0.17, 0.48)	0.33 (0.17, 0.47)			0.34 (0.14, 0.48)	0.33 (0.16, 0.47)			0.34 (0.15, 0.48)	0.31 (0.14, 0.47)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.121 (0.09, 0.25)	0.131 (0.086, 0.281)			0.136 (0.077, 0.384)	0.157 (0.082, 0.43)			0.145 (0.084, 0.437)	0.14 (0.081, 0.385)			0.145 (0.078, 0.334)	0.174 (0.093, 0.455)
DRD+	Hormone_therapies	count					111	111	111	111					111	111	111	111
		time					30 (23, 35)	30 (23, 35)	30 (23, 35)	30 (23, 35)					30 (23, 35)	30 (23, 35)	30 (23, 35)	30 (23, 35)
		n					4 (1, 14)	4 (1, 11)	5 (1, 9)	4 (1, 9)					4 (1, 10)	4 (1, 9)	4 (1, 9)	4 (1, 8)
		post_p					0.27 (0.11, 0.41)	0.28 (0.09, 0.45)	0.33 (0.16, 0.47)	0.34 (0.19, 0.46)					0.34 (0.17, 0.47)	0.34 (0.17, 0.47)	0.34 (0.17, 0.47)	0.32 (0.21, 0.46)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.148 (0.1, 0.596)	0.154 (0.084, 0.423)	0.136 (0.086, 0.497)	0.155 (0.084, 0.701)					0.14 (0.079, 0.564)	0.148 (0.081, 0.44)	0.149 (0.082, 0.517)	0.149 (0.09, 0.404)
	Carboplatin	count					183	183	183	183					183	183	183	183
		time					26 (17, 34)	26 (17, 34)	26 (17, 34)	26 (17, 34)					26 (17, 34)	26 (17, 34)	26 (17, 34)	26 (17, 34)
		n					7 (3, 17)	7 (2, 17)	4 (2, 10)	4 (1, 9)					3 (1, 9)	5 (1, 10)	4 (1, 9)	4 (1, 9)
		post_p					0.28 (0.09, 0.47)	0.3 (0.11, 0.47)	0.34 (0.16, 0.48)	0.35 (0.16, 0.48)					0.32 (0.14, 0.48)	0.33 (0.14, 0.47)	0.31 (0.17, 0.45)	0.33 (0.15, 0.47)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.136 (0.088, 0.308)	0.129 (0.088, 0.288)	0.127 (0.078, 0.334)	0.152 (0.088, 0.477)					0.16 (0.083, 0.548)	0.131 (0.085, 0.347)	0.162 (0.081, 0.487)	0.149 (0.082, 0.47)
	Niraparib	count					175	175	175	175					175	175	175	175
		time					24 (16, 34)	24 (16, 34)	24 (16, 34)	24 (16, 34)					24 (16, 34)	24 (16, 34)	24 (16, 34)	24 (16, 34)
		n					7 (3, 13)	6 (2, 13)	4 (1, 9)	4 (1, 8)					4 (1, 9)	4 (1, 9)	4 (2, 9)	3 (1, 8)
		post_p					0.3 (0.11, 0.46)	0.3 (0.1, 0.47)	0.34 (0.18, 0.47)	0.34 (0.17, 0.47)					0.32 (0.17, 0.48)	0.34 (0.16, 0.48)	0.33 (0.17, 0.47)	0.3 (0.16, 0.46)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.129 (0.087, 0.25)	0.139 (0.088, 0.37)	0.144 (0.082, 0.457)	0.151 (0.082, 0.521)					0.146 (0.087, 0.564)	0.147 (0.082, 0.517)	0.15 (0.079, 0.365)	0.17 (0.091, 0.483)
TEfus+	Hormone_therapies	count		198		198		198		198		198		198		198		198
		time		26 (17, 34)		26 (17, 34)		26 (17, 34)		26 (17, 34)		26 (17, 34)		26 (17, 34)		26 (17, 34)		26 (17, 34)
		n		5 (3, 13)		11 (4, 25)		3 (1, 12)		3 (0, 8)		4 (2, 11)		4 (2, 10)		3 (1, 8)		3 (1, 8)
		post_p		0.28 (0.1, 0.46)		0.27 (0.06, 0.46)		0.34 (0.16, 0.45)		0.36 (0.19, 0.48)		0.3 (0.13, 0.46)		0.28 (0.14, 0.47)		0.36 (0.19, 0.47)		0.35 (0.2, 0.47)
		r_prob		0.35 (0.35, 0.35)		0.18 (0.18, 0.18)		0 (0, 0)		0 (0, 0)		0.18 (0.18, 0.18)		0.12 (0.12, 0.12)		0 (0, 0)		0 (0, 0)
		rate		0.138 (0.086, 0.302)		0.117 (0.079, 0.226)		0.15 (0.089, 0.419)		0.148 (0.079, 0.562)		0.145 (0.082, 0.372)		0.132 (0.087, 0.45)		0.141 (0.082, 0.415)		0.15 (0.081, 0.43)
	Carboplatin	count		191		191		191		191		191		191		191		191
		time		25 (17, 34)		25 (17, 34)		25 (17, 34)		25 (17, 34)		25 (17, 34)		25 (17, 34)		25 (17, 34)		25 (17, 34)
		n		5 (2, 13)		9 (3, 22)		7 (3, 17)		4 (2, 9)		4 (2, 10)		4 (1, 10)		4 (1, 9)		4 (1, 9)
		post_p		0.31 (0.11, 0.48)		0.23 (0.06, 0.46)		0.32 (0.1, 0.47)		0.34 (0.17, 0.47)		0.33 (0.15, 0.47)		0.32 (0.17, 0.45)		0.32 (0.14, 0.46)		0.31 (0.16, 0.44)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.136 (0.078, 0.345)		0.127 (0.087, 0.26)		0.128 (0.08, 0.331)		0.146 (0.091, 0.477)		0.138 (0.08, 0.524)		0.133 (0.083, 0.454)		0.143 (0.086, 0.4)		0.15 (0.088, 0.505)
	Niraparib	count		209		209		209		209		209		209		209		209
		time		23 (15, 35)		23 (15, 35)		23 (15, 35)		23 (15, 35)		23 (15, 35)		23 (15, 35)		23 (15, 35)		23 (15, 35)
		n		4 (1, 11)		8 (3, 20)		6 (2, 14)		4 (1, 9)		4 (1, 10)		3 (1, 10)		4 (1, 9)		4 (2, 8)
		post_p		0.31 (0.14, 0.47)		0.26 (0.1, 0.48)		0.3 (0.1, 0.47)		0.34 (0.17, 0.47)		0.31 (0.14, 0.46)		0.32 (0.16, 0.48)		0.33 (0.15, 0.48)		0.3 (0.14, 0.45)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.143 (0.086, 0.519)		0.127 (0.079, 0.271)		0.136 (0.08, 0.349)		0.15 (0.086, 0.434)		0.145 (0.076, 0.565)		0.149 (0.084, 0.38)		0.148 (0.082, 0.455)		0.163 (0.091, 0.473)